FGF2

Gene Symbol	FGF2
Entrez Gene	2247
Alt Symbol	BFGF, FGF-2, FGFB, HBGF-2
Species	Human
Gene Type	protein-coding
Description	fibroblast growth factor 2 (basic)
Other Description	basic fibroblast growth factor bFGF|fibroblast growth factor 2|heparin-binding growth factor 2|prostatropin
Swissprots	Q9UCS6 Q9UCS5 P09038 O00527 P78443 Q16443 Q7KZ11 Q7KZ72 A4LBB8 Q5PY50 Q9UC54
Accessions	AAB21432 ABO43041 ADL14514 CAA28027 CAA28028 CAA28029 CAA73868 EAX05222 P09038 AA256481 AB451321 BAG70135 AB451450 BAG70264 AY820133 AAV70487 BC111737 BC166646 AAI66646 BE439775 BP292299 BU501243 CN315083 J04513 AAA52531 M17599 AAA52534 M27968 AAA52448 S47380 AAD13853 NM_002006 NP_001997
Function	Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. {ECO:0000269|PubMed:1721615, ECO:0000269|PubMed:8663044}.
Subcellular Location	Secreted. Nucleus. Note=Exported from cells by an endoplasmic reticulum (ER)/Golgi-independent mechanism. Unconventional secretion of FGF2 occurs by direct translocation across the plasma membrane. Binding of exogenous FGF2 to FGFR facilitates endocytosis followed by translocation of FGF2 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as CEP57.
Tissue Specificity	Expressed in granulosa and cumulus cells. Expressed in hepatocellular carcinoma cells, but not in non- cancerous liver tissue. {ECO:0000269|PubMed:1417798, ECO:0000269|PubMed:1721615}.
Top Pathways	Melanoma, MAPK signaling pathway, PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Rap1 signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

FGF basic (FGF2) Human ELISA Kit - ab99980 from Abcam Category ELISA Kit Prices $489.00 Sizes 1 x 96 tests Sensitivity < 50 pg/ml Range 102.4 pg/ml - 10000 pg/ml

FGF basic (FGF2) Human ELISA Kit - ab99979 from Abcam Category ELISA Kit Prices $489.00 Sizes 1 x 96 tests Sensitivity < 50 pg/ml Range 102.4 pg/ml - 10000 pg/ml

Mouse FGF2 / Basic FGF ELISA Kit - LS-F5598 from LifeSpan Bioscience Category ELISA Kit Sensitivity 5.5 pg/ml Range 15.625 - 1000 pg/ml (depending on sample type)

Human FGF2 / Basic FGF ELISA Kit (Competitive EIA) - LS-F5597 from LifeSpan Bioscience Category ELISA Kit Prices $490.00 Sizes 1 plate Sensitivity 4.66 pg/ml Range 18.8-600 pg/ml

Rat FGF2 / Basic FGF ELISA Kit (Competitive EIA) - LS-F5599 from LifeSpan Bioscience Category ELISA Kit Prices $630.00 Sizes 1 plate Sensitivity 5.74 pg/ml Range 18.8-600 pg/ml

Chicken FGF2 / Basic FGF ELISA Kit (Sandwich ELISA) - LS-F4751 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 6.3 pg/ml Range 18.8-600 pg/ml

Rabbit FGF2 / Basic FGF ELISA Kit (Sandwich ELISA) - LS-F5383 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 15.63 pg/ml Range 18.8-600 pg/ml

Pig FGF2 / Basic FGF ELISA Kit - LS-F5881 from LifeSpan Bioscience Category ELISA Kit Prices $780.00 Sizes 1 plate Sensitivity 3.2 pg/ml Range 7.813 - 500 pg/ml

Cow FGF2 / Basic FGF ELISA Kit - LS-F6316 from LifeSpan Bioscience Category ELISA Kit Prices $780.00 Sizes 1 plate Sensitivity 6.5 pg/ml Range 15.625 - 1000 pg/ml

Human FGF2 / Basic FGF ELISA Kit (Sandwich ELISA) - LS-F36 from LifeSpan Bioscience Category ELISA Kit Prices $460.00, $840.00, $1,960.00 Sizes 1 plate, 2 plate, 5 plate Sensitivity 102.4 pg/ml Range 18.8-600 pg/ml

Mouse FGF2 / Basic FGF ELISA Kit (Sandwich ELISA) - LS-F221 from LifeSpan Bioscience Category ELISA Kit Prices $460.00, $840.00, $1,960.00 Sizes 1 plate, 2 plate, 5 plate Sensitivity 18.8 pg/ml Range 18.8-600 pg/ml

Human FGF2 / Basic FGF ELISA Kit (Sandwich ELISA) - LS-F955 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 18.8-600 pg/ml

Mouse FGF2 / Basic FGF ELISA Kit (Competitive EIA) - LS-F9883 from LifeSpan Bioscience Category ELISA Kit Prices $670.00 Sizes 1 plate Sensitivity 4.41 pg/ml Range 18.8-600 pg/ml

Pig FGF2 / Basic FGF ELISA Kit (Competitive EIA) - LS-F9829 from LifeSpan Bioscience Category ELISA Kit Prices $780.00 Sizes 1 plate Sensitivity 4.14 pg/ml Range 18.8-600 pg/ml

Rat FGF2 / Basic FGF ELISA Kit (Sandwich ELISA) - LS-F11455 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 15.6 Range 18.8-600 pg/ml

Human FGF2 / Basic FGF ELISA Kit (Sandwich ELISA) - LS-F11454 from LifeSpan Bioscience Category ELISA Kit Prices $530.00 Sizes 1 plate Sensitivity 15.6 Range 18.8-600 pg/ml

Human bFGF ELISA Kit - RAB0183 from Sigma-Aldrich Category ELISA Kit Prices $438.50 Sizes 1 kt

Human bFGF ELISA Kit - RAB0182 from Sigma-Aldrich Category ELISA Kit Prices $423.50 Sizes 1 kt

Human FGF basic Biotinylated Fluorokine Flow Cytometry Kit - NFFB0 from R&D Systems Prices $405.00 Sizes 1 kit

Human FGF basic Quantikine ELISA Kit - DFB50 from R&D Systems Category ELISA Kit Prices $509.00, $2,440.00, $16,540.00 Sizes 1 kit, 1 pack (6 Plates), 1 pack (50 Plates) Sensitivity 3 pg/mL Range 10.0 - 640 pg/mL (Cell Culture Supernates, Serum, EDTA Plasma)

Human FGF basic Quantikine PharmPak (50 Plates) - PDFB50 from R&D Systems Category ELISA Kit Sensitivity 3 pg/mL Range 10 - 640 pg/mL (Serum, Cell Culture Supernates, EDTA Plasma)

Human FGF basic Quantikine SixPak (6 Plates) - SFB50 from R&D Systems Category ELISA Kit Sensitivity 3 pg/mL Range 10 - 640 pg/mL (Serum, Cell Culture Supernates, EDTA Plasma)

Human FGF basic Quantikine HS ELISA Kit - HSFB00D from R&D Systems Category ELISA Kit Prices $599.00, $2,875.00, $19,468.00 Sizes 1 kit, 1 pack (6 Plates), 1 pack (50 Plates) Sensitivity 0.07 pg/mL Range 0.3 - 20 pg/mL (Serum, EDTA Plasma, Heparin Plasma, Citrate Plasma, Urine)

Human FGF basic Quantikine HS PharmPak (50 Plates) - PHSFB00D from R&D Systems Category ELISA Kit Sensitivity 0.07 pg/mL Range 0.313 - 20 pg/mL (Serum, Heparin Plasma, EDTA Plasma, Urine, Citrate Plasma)

Human FGF basic Quantikine HS SixPak (6 Plates) - SSFB00D from R&D Systems Category ELISA Kit Sensitivity 0.07 pg/mL Range 0.313 - 20 pg/mL (Serum, Heparin Plasma, EDTA Plasma, Urine, Citrate Plasma)

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