FGF2

Gene Symbol FGF2
Entrez Gene 2247
Alt Symbol BFGF, FGF-2, FGFB, HBGF-2
Species Human
Gene Type protein-coding
Description fibroblast growth factor 2 (basic)
Other Description basic fibroblast growth factor bFGF|fibroblast growth factor 2|heparin-binding growth factor 2|prostatropin
Swissprots Q9UCS6 Q9UCS5 P09038 O00527 P78443 Q16443 Q7KZ11 Q7KZ72 A4LBB8 Q5PY50 Q9UC54
Accessions AAB21432 ABO43041 ADL14514 CAA28027 CAA28028 CAA28029 CAA73868 EAX05222 P09038 AA256481 AB451321 BAG70135 AB451450 BAG70264 AY820133 AAV70487 BC111737 BC166646 AAI66646 BE439775 BP292299 BU501243 CN315083 J04513 AAA52531 M17599 AAA52534 M27968 AAA52448 S47380 AAD13853 NM_002006 NP_001997
Function Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. {ECO:0000269|PubMed:1721615, ECO:0000269|PubMed:8663044}.
Subcellular Location Secreted. Nucleus. Note=Exported from cells by an endoplasmic reticulum (ER)/Golgi-independent mechanism. Unconventional secretion of FGF2 occurs by direct translocation across the plasma membrane. Binding of exogenous FGF2 to FGFR facilitates endocytosis followed by translocation of FGF2 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as CEP57.
Tissue Specificity Expressed in granulosa and cumulus cells. Expressed in hepatocellular carcinoma cells, but not in non- cancerous liver tissue. {ECO:0000269|PubMed:1417798, ECO:0000269|PubMed:1721615}.
Top Pathways Melanoma, MAPK signaling pathway, PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Rap1 signaling pathway

Basic FGF (19A9) Rabbit mAb - 3196 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone 19A9
Western blot analysis of recombinant human basic FGF proteins at various concentrations, using Basic FGF (19A9) Rabbit mAb.

FGF-2 (A-1) - sc-271847 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
FGF-2 (A-1): sc-271847. Western blot analysis of human recombinant FGF-2.

FGF-2 (C-18) - sc-1360 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
FGF-2 (C-18): sc-1360. Immunofluorescence staining of methanol-fixed COLO 320DM cells showing cytoplasmic localization.

FGF-2 (G-2) - sc-365106 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
FGF-2 (G-2): sc-365106. Western blot analysis of human recombinant FGF-2.

FGF-2 (C-2) - sc-74412 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
FGF-2 (C-2): sc-74412. Western blot analysis of human recombinant FGF-2.

FGF-2 (A-7) - sc-74413 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
FGF-2 (A-7): sc-74413. Western blot analysis of human recombinant FGF-2.

FGF-2 (6) - sc-136255 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
FGF-2 (6): sc-136255. Western blot analysis of FGF-2 expression in HeLa whole cell lysate.

FGF-2 (N-19) - sc-1390 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Western blot analysis of human recombinant FGF-2. Antibodies tested include FGF-2 (N-19): sc-1390 (A), FGF-2 (H-131): sc-7911 (B) and FGF-2 (C-18): sc-1360 (C).

FGF-2 (H-131) - sc-7911 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Western blot analysis of human recombinant FGF-2. Antibodies tested include FGF-2 (N-19): sc-1390 (A), FGF-2 (H-131): sc-7911 (B) and FGF-2 (C-18): sc-1360 (C).

FGF-2 (147) - sc-79 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
FGF-2 (147): sc-79-G. Immunoperoxidase staining of formalin fixed, paraffin-embedded human smooth muscle tissue showing cytoplasmic and nuclear staining of smooth muscle cells.

Anti-FGF basic antibody - ab8880 from Abcam

Prices $379.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab8880 stained HepG2 cells. The cells were 100% methanol fixed (5 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab8880, 1/200 dilution) overnight at +4°C. The secondary antibody (green) was ab96899, DyLight® 488 goat anti-rabbit IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-FGF basic antibody - ab72316 from Abcam

Prices $387.00
Sizes 150 µl
Host Rabbit
Clonality Polyclonal
ab72316 stained HepG2 cells. The cells were 100% methanol fixed (5 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody ab72316 at 1/1000 dilution overnight at +4°C. The secondary antibody (green) was DyLight® 488 goat anti- rabbit (ab96899) IgG (H+L) used at a 1/1000 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-FGF basic antibody - ab64207 from Abcam

Host Sheep
Clonality Polyclonal

Anti-FGF basic antibody - ab105087 from Abcam

Host Goat
Clonality Polyclonal

Anti-FGF basic antibody - ab195572 from Abcam

Prices $370.00
Sizes 250 µg
Host Rabbit
Clonality Polyclonal

Anti-FGF basic antibody - ab58618 from Abcam

Prices $372.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-FGF basic antibody - ab109613 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-FGF basic antibody - ab8881 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-FGF basic antibody - ab10420 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-FGF basic antibody - ab11937 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-FGF basic antibody (ab11937)Lane 1 : Recombinant fragment human FGF basicLane 2 : Recombinant fragment mouse FGF basicLane 3 : Recombinant fragment rat FGF basic

Anti-FGF basic antibody - ab73976 from Abcam

Prices $370.00
Sizes 100 µl
Host Chicken
Clonality Polyclonal

Anti-FGF basic antibody - ab10421 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-FGF basic antibody - ab6209 from Abcam

Prices $370.00
Sizes 100 µl
Host Sheep
Clonality Polyclonal

Anti-FGF basic antibody - ab6210 from Abcam

Prices $370.00
Sizes 100 µl
Host Sheep
Clonality Polyclonal

Anti-FGF basic antibody - ab17505 from Abcam

Prices $370.00
Sizes 250 µg
Host Mouse
Clonality Monoclonal
Search more