HCN2

Gene Symbol HCN2
Entrez Gene 610
Alt Symbol BCNG-2, BCNG2, HAC-1
Species Human
Gene Type protein-coding
Description hyperpolarization activated cyclic nucleotide gated potassium channel 2
Other Description brain cyclic nucleotide gated channel 2|brain cyclic nucleotide-gated channel 2|hyperpolarization activated cyclic nucleotide-gated potassium channel 2|potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
Swissprots O60742 O75267 Q9UL51 Q9UBS2 O60743
Accessions AAC33280 CAB42630 CCF23298 EAW61179 Q9UL51 AF064877 AAC39760 AF065164 AAC28444 AJ012582 CAB42602 BC039619 BC118001 AAI18002 DQ854815 ABI75145 NM_001194 NP_001185
Function Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Can also transport ammonium in the distal nephron. Produces a large instantaneous current. Modulated by intracellular chloride ions and pH; acidic pH shifts the activation to more negative voltages (By similarity). {ECO:0000250}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:10228147, ECO:0000269|PubMed:10524219}; Multi-pass membrane protein {ECO:0000269|PubMed:10228147, ECO:0000269|PubMed:10524219}.
Tissue Specificity Highly expressed throughout the brain. Detected at low levels in heart. {ECO:0000269|PubMed:10228147, ECO:0000269|PubMed:9630217}.
Top Pathways cAMP signaling pathway

HCN2 (D1C6I) Rabbit mAb - 14957 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D1C6I
Western blot analysis of extracts from various tissues using HCN2 (D1C6I) Rabbit mAb (upper) and β-Actin (D6A8) Rabbit mAb #8457 (lower).

HCN2 (N-13) - sc-19708 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
HCN2 (N-13): sc-19708. Western blot analysis of HCN2 expression in SK-N-SH (A), IMR-32 (B) and H4 (C) whole cell lysates.

HCN2 (C-20) - sc-19710 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-HCN2 antibody - ab65704 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab65704 stained SKNSH cells. The cells were 100% methanol fixed (5 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab65704, 5µg/ml) overnight at +4°C. The secondary antibody (green) was ab96899, DyLight® 488 goat anti-rabbit IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-HCN2 antibody - ab19346 from Abcam

Prices $382.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab19346 has been successfully used in Western blot procedures. By Western blot, this antibody detects bands at ~100 kDa and ~115 kDa representing the non-glycosylated and glycosylated form of HCN2 in rat brain extract.

Anti-HCN2 antibody - ab74734 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-HCN2 antibody - ab136839 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-HCN2 antibody (ab136839) at 1/500 dilution + HT29 cell lysate at 30 µg

Anti-HCN2 Antibody (aa761-863, clone S71-37, Atto 390) - LS-C230639 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S71-37

Anti-HCN2 Antibody (C-Terminus) - LS-C153519 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-HCN2 Antibody (aa761-863, clone S71-37, Atto 565) - LS-C230642 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S71-37

Anti-HCN2 Antibody (aa761-863, clone S71-37, Atto 488) - LS-C230641 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S71-37

Anti-HCN2 Antibody (aa761-863, clone S71-37, Atto 594) - LS-C230643 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S71-37

Anti-HCN2 Antibody (aa761-863, clone S71-37, Atto 633) - LS-C230644 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S71-37

Anti-HCN2 Antibody (aa761-863, clone S71-37, Atto 680) - LS-C230646 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S71-37

Anti-HCN2 Antibody (aa761-863, clone S71-37, Atto 655) - LS-C230645 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S71-37

Anti-HCN2 Antibody (aa761-863, clone S71-37, Atto 700) - LS-C230647 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S71-37

Anti-HCN2 Antibody (aa761-863, clone S71-37, FITC) - LS-C230651 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S71-37

Anti-HCN2 Antibody (aa761-863, clone S71-37, AP) - LS-C230648 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S71-37

Anti-HCN2 Antibody (Glu521) - LS-C177488 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of HCN2 (E521) pAb in extracts from Jurkat cells.

Anti-HCN2 Antibody (aa761-863, clone S71-37, Biotin) - LS-C230650 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S71-37

Anti-HCN2 Antibody (aa761-863, clone S71-37, APC) - LS-C230649 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S71-37

Anti-HCN2 Antibody (aa491-540) - LS-C120240 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from Jurkat cells, using HCN2 Antibody. The lane on the right is treated with the synthesized peptide.

Anti-HCN2 Antibody (aa761-863, clone S71-37, PE, Atto 594) - LS-C230653 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S71-37

Anti-HCN2 Antibody (aa761-863, clone S71-37, RPE) - LS-C230655 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S71-37

Anti-HCN2 Antibody (aa472-521) - LS-C292045 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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