| Gene Symbol |
HCN2
|
| Entrez Gene |
610
|
| Alt Symbol |
BCNG-2, BCNG2, HAC-1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
hyperpolarization activated cyclic nucleotide gated potassium channel 2
|
| Other Description |
brain cyclic nucleotide gated channel 2|brain cyclic nucleotide-gated channel 2|hyperpolarization activated cyclic nucleotide-gated potassium channel 2|potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
|
| Swissprots |
O60742 O75267 Q9UL51 Q9UBS2 O60743
|
| Accessions |
AAC33280 CAB42630 CCF23298 EAW61179 Q9UL51 AF064877 AAC39760 AF065164 AAC28444 AJ012582 CAB42602 BC039619 BC118001 AAI18002 DQ854815 ABI75145 NM_001194 NP_001185
|
| Function |
Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Can also transport ammonium in the distal nephron. Produces a large instantaneous current. Modulated by intracellular chloride ions and pH; acidic pH shifts the activation to more negative voltages (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:10228147, ECO:0000269|PubMed:10524219}; Multi-pass membrane protein {ECO:0000269|PubMed:10228147, ECO:0000269|PubMed:10524219}.
|
| Tissue Specificity |
Highly expressed throughout the brain. Detected at low levels in heart. {ECO:0000269|PubMed:10228147, ECO:0000269|PubMed:9630217}.
|
| Top Pathways |
cAMP signaling pathway
|