HCN2

Gene Symbol	HCN2
Entrez Gene	610
Alt Symbol	BCNG-2, BCNG2, HAC-1
Species	Human
Gene Type	protein-coding
Description	hyperpolarization activated cyclic nucleotide gated potassium channel 2
Other Description	brain cyclic nucleotide gated channel 2|brain cyclic nucleotide-gated channel 2|hyperpolarization activated cyclic nucleotide-gated potassium channel 2|potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
Swissprots	O60742 O75267 Q9UL51 Q9UBS2 O60743
Accessions	AAC33280 CAB42630 CCF23298 EAW61179 Q9UL51 AF064877 AAC39760 AF065164 AAC28444 AJ012582 CAB42602 BC039619 BC118001 AAI18002 DQ854815 ABI75145 NM_001194 NP_001185
Function	Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Can also transport ammonium in the distal nephron. Produces a large instantaneous current. Modulated by intracellular chloride ions and pH; acidic pH shifts the activation to more negative voltages (By similarity). {ECO:0000250}.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:10228147, ECO:0000269|PubMed:10524219}; Multi-pass membrane protein {ECO:0000269|PubMed:10228147, ECO:0000269|PubMed:10524219}.
Tissue Specificity	Highly expressed throughout the brain. Detected at low levels in heart. {ECO:0000269|PubMed:10228147, ECO:0000269|PubMed:9630217}.
Top Pathways	cAMP signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

HCN2 CRISPR/Cas9 KO Plasmid (h) - sc-405074 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

HCN2 HDR Plasmid (h) - sc-405074-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

HCN2 Double Nickase Plasmid (h) - sc-405074-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

HCN2 Double Nickase Plasmid (h2) - sc-405074-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

HCN2 CRISPR Activation Plasmid (h) - sc-405074-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

HCN2 CRISPR Activation Plasmid (h2) - sc-405074-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

HCN2 Lentiviral Activation Particles (h) - sc-405074-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

HCN2 Lentiviral Activation Particles (h2) - sc-405074-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

HCN2 siRNA (h) - sc-35537 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

HCN2 shRNA Plasmid (h) - sc-35537-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

HCN2 shRNA (h) Lentiviral Particles - sc-35537-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

HCN2 RNAi - H00000610-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU049531 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN9925 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9925 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

HCN2 siRNA (Human) - CRH0418 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

HCN2 - MBS8230491 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

HCN2 CRISPR/Cas9 KO Plasmid (h2) - sc-405074-KO-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

HCN2 HDR Plasmid (h2) - sc-405074-HDR-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

shRNA set against Human HCN2 (NM_001194.3) - SHH310833 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human HCN2(NM_001194.3) - SHH115661 from Creative biogene Category siRNA Species Reactivities Human

Human HCN2 siRNA - orb260920 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

HCN2 shRNA Plasmid (Human) - CHH0418 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

HCN2 miRNA 3'UTR clone - MiUTR1H-04409 from Creative biogene Species Reactivities Human

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