| Gene Symbol | EIF2S1 |
|---|---|
| Entrez Gene | 1965 |
| Alt Symbol | EIF-2, EIF-2A, EIF-2alpha, EIF2, EIF2A |
| Species | Human |
| Gene Type | protein-coding |
| Description | eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa |
| Other Description | eIF-2-alpha|eukaryotic translation initiation factor 2 subunit 1|eukaryotic translation initiation factor 2 subunit alpha |
| Swissprots | P05198 |
| Accessions | EAW80933 EAW80934 P05198 AK297244 BAG59724 AK312442 BAG35351 BC002513 AAH02513 BX161521 CAD61953 D28379 BAA05745 DQ892151 ABM83077 DQ895347 ABM86273 J02645 AAA52373 U26032 NM_004094 NP_004085 |
| Function | Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B. |
| Subcellular Location | Cytoplasmic granule {ECO:0000250}. Note=The cytoplasmic granules are stress granules which are a dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. Colocalizes with NANOS3 in the stress granules (By similarity). {ECO:0000250}. |
| Top Pathways | Protein processing in endoplasmic reticulum, RNA transport, Hepatitis C, Measles, Influenza A |