EIF2S1

Gene Symbol EIF2S1
Entrez Gene 1965
Alt Symbol EIF-2, EIF-2A, EIF-2alpha, EIF2, EIF2A
Species Human
Gene Type protein-coding
Description eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
Other Description eIF-2-alpha|eukaryotic translation initiation factor 2 subunit 1|eukaryotic translation initiation factor 2 subunit alpha
Swissprots P05198
Accessions EAW80933 EAW80934 P05198 AK297244 BAG59724 AK312442 BAG35351 BC002513 AAH02513 BX161521 CAD61953 D28379 BAA05745 DQ892151 ABM83077 DQ895347 ABM86273 J02645 AAA52373 U26032 NM_004094 NP_004085
Function Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.
Subcellular Location Cytoplasmic granule {ECO:0000250}. Note=The cytoplasmic granules are stress granules which are a dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. Colocalizes with NANOS3 in the stress granules (By similarity). {ECO:0000250}.
Top Pathways Protein processing in endoplasmic reticulum, RNA transport, Hepatitis C, Measles, Influenza A

eIF2α CRISPR/Cas9 KO Plasmid (h) - sc-400199 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

eIF2α HDR Plasmid (h) - sc-400199-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

eIF2α Double Nickase Plasmid (h) - sc-400199-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

eIF2α Double Nickase Plasmid (h2) - sc-400199-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

eIF2α CRISPR Activation Plasmid (h) - sc-400199-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

eIF2α CRISPR Activation Plasmid (h2) - sc-400199-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

eIF2α Lentiviral Activation Particles (h) - sc-400199-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

eIF2α Lentiviral Activation Particles (h2) - sc-400199-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

eIF2α siRNA (h) - sc-35272 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

eIF2α shRNA Plasmid (h) - sc-35272-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

eIF2α shRNA (h) Lentiviral Particles - sc-35272-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

eIF2 alpha/EIF2S1 RNAi - H00001965-R01V from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human
Western Blot: eIF2 alpha/EIF2S1 RNAi [H00001965-R01V] - Analysis of EIF2S1 over-expressed 293 cell line, cotransfected with EIF2S1 Validated Chimera RNAi or non-transfected control. Blot probed with H00001965-M01. GAPDH (36.1 kDa) used as loading control.

eIF2 alpha/EIF2S1 RNAi - H00001965-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU054441 from Sigma-Aldrich

Category siRNA

CompoZr® Knockout ZFN Kit - CKOZFN7754 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7754 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

EIF2S1 siRNA (Human) - CRH1360 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

EIF2S1 - MBS8213108 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

EIF2S1 shRNA Plasmid (Human) - CHH1360 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
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