IKZF4

Gene Symbol	IKZF4
Entrez Gene	64375
Alt Symbol	EOS, ZNFN1A4
Species	Human
Gene Type	protein-coding
Description	IKAROS family zinc finger 4 (Eos)
Other Description	ikaros family zinc finger protein 4\|zinc finger protein Eos\|zinc finger protein, subfamily 1A, 4 (Eos)\|zinc finger transcription factor Eos
Swissprots	Q9H2S9 Q96JP3
Accessions	EAW96872 EAW96873 EAW96874 Q9H2S9 AB058685 BAB47411 AF230809 AAG39221 AK055063 AK122880 BAG53777 AK314543 BAG37131 BC160169 AAI60169 BX647761 DA797441 XM_005269086 XP_005269143 XM_005269089 XP_005269146 XM_005269090 XP_005269147 XM_005269091 XP_005269148 XM_005269092 XP_005269149 XM_005269093 XP_005269150 XM_006719561 XP_006719624 XM_011538664 XP_011536966 XM_011538665 XP_011536967 XM_011538666 XP_011536968 XM_011538667 XP_011536969 XM_011538668 XP_011536970 XM_011538669 XP_011536971 XM_011538670 XP_011536972 NM_022465 NP_071910
Function	DNA-binding protein that binds to the 5'GGGAATRCC-3' Ikaros-binding sequence. Transcriptional repressor. Interacts with SPI1 and MITF to repress transcription of the CTSK and ACP5 promoters via recruitment of corepressors SIN3A and CTBP2. May be involved in the development of central and peripheral nervous systems. Essential for the inhibitory function of regulatory T- cells (Treg). Mediates FOXP3-mediated gene silencing in regulatory T-cells (Treg) via recruitment of corepressor CTBP1 (By similarity). {ECO:0000250\|UniProtKB:Q8C208, ECO:0000269\|PubMed:10978333, ECO:0000269\|PubMed:12015313, ECO:0000269\|PubMed:12444977}.
Subcellular Location	Nucleus {ECO:0000269\|PubMed:12444977}.
Tissue Specificity	Highly expressed in skeletal muscle, low levels of expression in heart, thymus, kidney, liver, and spleen. Expressed in the hematopoietic cell lines MOLT-4, NALM-6 and K- 562. Highly expressed in THP-1 and M-07e cell lines, which have characteristics of myeloid and early megakaryocytic cells respectively. {ECO:0000269\|PubMed:10978333}.

Eos (D-15) - sc-132306 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

Eos (E-13) - sc-132307 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

Eos (H-70) - sc-292209 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

Eos (L-12) - sc-132308 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

Eos (D-17) - sc-101983 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	100 µg/ml
Host	Rabbit
Clonality	Polyclonal

Eos (D-17): sc-101983. Western blot analysis of Eos expression in Hep G2 whole cell lysate.

Anti-ZNFN1A4 antibody - ab49285 from Abcam

Prices	$370.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Lane 1 : molecular weight markersLane 2 : Anti-ZNFN1A4 antibody (ab49285) at 1.25 µg/mlLane 1 : molecular weight markersLane 2 : HepG2 cell lysate at 10 µgSecondaryLane 1 : molecular weight markersLane 2 : HRP conjugated anti-Rabbit IgG at 1/50,000 -1/100,000 dilution

Anti-ZNFN1A4 antibody - ab183625 from Abcam

Prices	$370.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-ZNFN1A4 antibody (ab183625) at 1/1000 dilutionLane 1 : Raji whole cell lysateLane 2 : K562 whole cell lysateLysates/proteins at 30 µg per lane.

Anti-ZNFN1A4 antibody - ab135049 from Abcam

Prices	$370.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-ZNFN1A4 antibody (ab135049) at 1/1000 dilution + HepG2 total cell extractsSecondaryRabbit polyclonal to ZNFN1A4 (ab135049) at 1/5000 dilution

Anti-ZNFN1A4 antibody - ab136999 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-ZNFN1A4 antibody (ab136999) at 1/500 dilution + HeLa cell lysate at 30 µg

Anti-ZNFN1A4 antibody - ab56404 from Abcam

Host	Mouse
Clonality	Monoclonal

Western blot against tagged recombinant protein immunogen using ab56404 ZNFN1A4 antibody at 1ug/ml.

Anti-ZNFN1A4 antibody [EPR11804] - ab170957 from Abcam

Prices	$357.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR11804

Flow cytometry analysis of permeabilized THP1 cells labeling ZNFN1A4 (red), using ab170957 at a 1/10 dilution and negative control cells probed with a Rabbit IgG (green).

Anti-IKZF4 / EOS Antibody (aa309-323) - LS-C112678 from LifeSpan Bioscience

Prices	$335.00
Sizes	100 µg
Host	Goat
Clonality	Polyclonal

Anti-IKZF4 / ZNFN1A4 Antibody (Arg507) - LS-C193253 from LifeSpan Bioscience

Prices	$385.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-IKZF4 / EOS Antibody (aa458-507) - LS-C292092 from LifeSpan Bioscience

Prices	$315.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-IKZF4 / EOS Antibody - LS-C308435 from LifeSpan Bioscience

Prices	$455.00
Sizes	50 µg
Host	Mouse
Clonality	Polyclonal

Anti-IKZF4 / EOS Antibody - LS-C310729 from LifeSpan Bioscience

Prices	$495.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-IKZF4 / EOS Antibody (aa97-146) - LS-C31256 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-IKZF4 / EOS Antibody - LS-C310730 from LifeSpan Bioscience

Prices	$475.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-IKZF4 / EOS Antibody (aa21-70) - LS-C110403 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

IKZF4 / ZNFN1A4 antibody LS-C110403 Western blot of 721_B cell lysate.

ZNFN1A4 Antibody - H00064375-B01P from Novus Biologicals

Prices	$359.00
Sizes	50 µg
Host	Mouse
Clonality	Polyclonal

ZNFN1A4 Antibody - NBP2-14120 from Novus Biologicals

Prices	$419.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Immunohistochemistry-Paraffin: ZNFN1A4 Antibody [NBP2-14120] Staining of human stomach, upper shows strong granular cytoplasmic positivity in glandular cells.

ZNFN1A4 Antibody - H00064375-A01 from Novus Biologicals

Prices	$269.00
Sizes	50 µl
Host	Mouse
Clonality	Polyclonal

ZNFN1A4 Antibody (4E6) - H00064375-M01A from Novus Biologicals

Prices	$349.00
Sizes	200 µl
Host	Mouse
Clonality	Monoclonal
Clone	4E6

ZNFN1A4 Antibody - H00064375-D01P from Novus Biologicals

Prices	$399.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Western Blot: ZNFN1A4 Antibody [H00064375-D01P] - Analysis of IKZF4 expression in transfected 293T cell line by IKZF4 polyclonal antibody.Lane 1: IKZF4 transfected lysate(59.70 KDa).Lane 2: Non-transfected lysate.

ZNFN1A4 Antibody - H00064375-D01 from Novus Biologicals

Prices	$399.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

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