IKZF4

Gene Symbol	IKZF4
Entrez Gene	64375
Alt Symbol	EOS, ZNFN1A4
Species	Human
Gene Type	protein-coding
Description	IKAROS family zinc finger 4 (Eos)
Other Description	ikaros family zinc finger protein 4|zinc finger protein Eos|zinc finger protein, subfamily 1A, 4 (Eos)|zinc finger transcription factor Eos
Swissprots	Q9H2S9 Q96JP3
Accessions	EAW96872 EAW96873 EAW96874 Q9H2S9 AB058685 BAB47411 AF230809 AAG39221 AK055063 AK122880 BAG53777 AK314543 BAG37131 BC160169 AAI60169 BX647761 DA797441 XM_005269086 XP_005269143 XM_005269089 XP_005269146 XM_005269090 XP_005269147 XM_005269091 XP_005269148 XM_005269092 XP_005269149 XM_005269093 XP_005269150 XM_006719561 XP_006719624 XM_011538664 XP_011536966 XM_011538665 XP_011536967 XM_011538666 XP_011536968 XM_011538667 XP_011536969 XM_011538668 XP_011536970 XM_011538669 XP_011536971 XM_011538670 XP_011536972 NM_022465 NP_071910
Function	DNA-binding protein that binds to the 5'GGGAATRCC-3' Ikaros-binding sequence. Transcriptional repressor. Interacts with SPI1 and MITF to repress transcription of the CTSK and ACP5 promoters via recruitment of corepressors SIN3A and CTBP2. May be involved in the development of central and peripheral nervous systems. Essential for the inhibitory function of regulatory T- cells (Treg). Mediates FOXP3-mediated gene silencing in regulatory T-cells (Treg) via recruitment of corepressor CTBP1 (By similarity). {ECO:0000250|UniProtKB:Q8C208, ECO:0000269|PubMed:10978333, ECO:0000269|PubMed:12015313, ECO:0000269|PubMed:12444977}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:12444977}.
Tissue Specificity	Highly expressed in skeletal muscle, low levels of expression in heart, thymus, kidney, liver, and spleen. Expressed in the hematopoietic cell lines MOLT-4, NALM-6 and K- 562. Highly expressed in THP-1 and M-07e cell lines, which have characteristics of myeloid and early megakaryocytic cells respectively. {ECO:0000269|PubMed:10978333}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human ZNFN1A4 full length protein - ab163824 from Abcam Category Protein Source Wheat germ Species Human

Human ZNFN1A4 protein fragment - ab163825 from Abcam Category Protein Source Wheat germ Species Human

Recombinant Human ZNFN1A4 Protein - H00064375-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human ZNFN1A4 Protein - H00064375-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

IKZF4 blocking peptide - GTX88207-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Bovine

ZNFN1A4 Peptide - AC21-2085-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

ZNFN1A4 / IKZF4 / EOS - H00064375-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

ZNFN1A4 / IKZF4 / EOS - H00064375-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

ZNFN1A4 / IKZF4 / EOS - H00064375-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

IKZF4 Peptide - 42-300P from ProSci Category Peptide Prices $175.00 Sizes 100 µg

Eos (R507) Peptide - BS9253P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human Zinc finger protein Eos(IKZF4) - CSB-YP887965HU CSB-EP887965HU CSB-BP887965HU CSB-MP887965HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Zinc finger protein Eos (IKZF4) , Recombinant Protein - MBS1289076 from MyBioSource Category Protein Prices $2,310.00, $2,310.00, $2,735.00, $2,735.00 Sizes 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

IKZF4, Peptide - MBS425879 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Dog, Bovine

ZNFN1A4 Protein - NBP2-14120PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

IKZF4 Peptide, Human - M34GP07526H from Creative Peptides Category Peptide Source Synthetic. Species Human

IKZF4 Immunizing peptide - orb59749 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg

IKZF4 Recombinant Protein Antigen - NBP2-55305PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

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