| Gene Symbol |
IKZF4
|
| Entrez Gene |
64375
|
| Alt Symbol |
EOS, ZNFN1A4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
IKAROS family zinc finger 4 (Eos)
|
| Other Description |
ikaros family zinc finger protein 4|zinc finger protein Eos|zinc finger protein, subfamily 1A, 4 (Eos)|zinc finger transcription factor Eos
|
| Swissprots |
Q9H2S9 Q96JP3
|
| Accessions |
EAW96872 EAW96873 EAW96874 Q9H2S9 AB058685 BAB47411 AF230809 AAG39221 AK055063 AK122880 BAG53777 AK314543 BAG37131 BC160169 AAI60169 BX647761 DA797441 XM_005269086 XP_005269143 XM_005269089 XP_005269146 XM_005269090 XP_005269147 XM_005269091 XP_005269148 XM_005269092 XP_005269149 XM_005269093 XP_005269150 XM_006719561 XP_006719624 XM_011538664 XP_011536966 XM_011538665 XP_011536967 XM_011538666 XP_011536968 XM_011538667 XP_011536969 XM_011538668 XP_011536970 XM_011538669 XP_011536971 XM_011538670 XP_011536972 NM_022465 NP_071910
|
| Function |
DNA-binding protein that binds to the 5'GGGAATRCC-3' Ikaros-binding sequence. Transcriptional repressor. Interacts with SPI1 and MITF to repress transcription of the CTSK and ACP5 promoters via recruitment of corepressors SIN3A and CTBP2. May be involved in the development of central and peripheral nervous systems. Essential for the inhibitory function of regulatory T- cells (Treg). Mediates FOXP3-mediated gene silencing in regulatory T-cells (Treg) via recruitment of corepressor CTBP1 (By similarity). {ECO:0000250|UniProtKB:Q8C208, ECO:0000269|PubMed:10978333, ECO:0000269|PubMed:12015313, ECO:0000269|PubMed:12444977}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:12444977}.
|
| Tissue Specificity |
Highly expressed in skeletal muscle, low levels of expression in heart, thymus, kidney, liver, and spleen. Expressed in the hematopoietic cell lines MOLT-4, NALM-6 and K- 562. Highly expressed in THP-1 and M-07e cell lines, which have characteristics of myeloid and early megakaryocytic cells respectively. {ECO:0000269|PubMed:10978333}.
|
