| Gene Symbol |
SCN11A
|
| Entrez Gene |
11280
|
| Alt Symbol |
FEPS3, HSAN7, NAV1.9, NaN, PN5, SCN12A, SNS-2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
sodium channel, voltage gated, type XI alpha subunit
|
| Other Description |
peripheral nerve sodium channel 5|sensory neuron sodium channel 2|sodium channel protein type 11 subunit alpha|sodium channel protein type XI subunit alpha|sodium channel, voltage-gated, type XI, alpha polypeptide|sodium channel, voltage-gated, type XI, alpha subunit|sodium channel, voltage-gated, type XII, alpha polypeptide|voltage-gated sodium channel subunit alpha Nav1.9
|
| Swissprots |
Q8NDX3 C9JR31 Q68K15 Q9UI33 Q9UHM0 A6NN05 C9JD48 Q9UHE0
|
| Accessions |
AAD53407 AAO85712 CAJ84379 EAW64544 EAW64545 EAW64546 Q9UI33 AF109737 AAF24976 AF150882 AAF24980 AF188679 AAF17480 AJ417790 CAD10507 AY686224 AAT95434 BC172234 AAI72234 XM_011533320 XP_011531622 XM_011533321 XP_011531623 XM_011533322 XP_011531624 NM_001287223 NP_001274152 NM_014139 NP_054858
|
| Function |
This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Also involved, with the contribution of the receptor tyrosine kinase NTRK2, in rapid BDNF-evoked neuronal depolarization. {ECO:0000269|PubMed:10580103, ECO:0000269|PubMed:12384689}.
|
| Subcellular Location |
Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
|
| Tissue Specificity |
Expressed in the dorsal root ganglia and trigeminal ganglia, olfactory bulb, hippocampus, cerebellar cortex, spinal cord, spleen, small intestine and placenta. {ECO:0000269|PubMed:10623608, ECO:0000269|PubMed:15302875}.
|