SCN11A
| Gene Symbol | SCN11A |
|---|---|
| Entrez Gene | 11280 |
| Alt Symbol | FEPS3, HSAN7, NAV1.9, NaN, PN5, SCN12A, SNS-2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | sodium channel, voltage gated, type XI alpha subunit |
| Other Description | peripheral nerve sodium channel 5|sensory neuron sodium channel 2|sodium channel protein type 11 subunit alpha|sodium channel protein type XI subunit alpha|sodium channel, voltage-gated, type XI, alpha polypeptide|sodium channel, voltage-gated, type XI, alpha subunit|sodium channel, voltage-gated, type XII, alpha polypeptide|voltage-gated sodium channel subunit alpha Nav1.9 |
| Swissprots | Q8NDX3 C9JR31 Q68K15 Q9UI33 Q9UHM0 A6NN05 C9JD48 Q9UHE0 |
| Accessions | AAD53407 AAO85712 CAJ84379 EAW64544 EAW64545 EAW64546 Q9UI33 AF109737 AAF24976 AF150882 AAF24980 AF188679 AAF17480 AJ417790 CAD10507 AY686224 AAT95434 BC172234 AAI72234 XM_011533320 XP_011531622 XM_011533321 XP_011531623 XM_011533322 XP_011531624 NM_001287223 NP_001274152 NM_014139 NP_054858 |
| Function | This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Also involved, with the contribution of the receptor tyrosine kinase NTRK2, in rapid BDNF-evoked neuronal depolarization. {ECO:0000269|PubMed:10580103, ECO:0000269|PubMed:12384689}. |
| Subcellular Location | Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. |
| Tissue Specificity | Expressed in the dorsal root ganglia and trigeminal ganglia, olfactory bulb, hippocampus, cerebellar cortex, spinal cord, spleen, small intestine and placenta. {ECO:0000269|PubMed:10623608, ECO:0000269|PubMed:15302875}. |
Na + CP type XIα CRISPR/Cas9 KO Plasmid (h) - sc-411597 from Santa Cruz Biotechnology
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Na + CP type XIα HDR Plasmid (h) - sc-411597-HDR from Santa Cruz Biotechnology
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Na + CP type XIα Double Nickase Plasmid (h) - sc-411597-NIC from Santa Cruz Biotechnology
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Na + CP type XIα Double Nickase Plasmid (h2) - sc-411597-NIC-2 from Santa Cruz Biotechnology
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Na + CP type XIα CRISPR Activation Plasmid (h) - sc-411597-ACT from Santa Cruz Biotechnology
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Na + CP type XIα CRISPR Activation Plasmid (h2) - sc-411597-ACT-2 from Santa Cruz Biotechnology
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Na + CP type XIα Lentiviral Activation Particles (h) - sc-411597-LAC from Santa Cruz Biotechnology
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Na + CP type XIα Lentiviral Activation Particles (h2) - sc-411597-LAC-2 from Santa Cruz Biotechnology
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Na+ CP type XIα siRNA (h) - sc-78209 from Santa Cruz Biotechnology
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Na+ CP type XIα shRNA Plasmid (h) - sc-78209-SH from Santa Cruz Biotechnology
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Na+ CP type XIα shRNA (h) Lentiviral Particles - sc-78209-V from Santa Cruz Biotechnology
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SCN11A RNAi - H00011280-R01 from Novus Biologicals
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MISSION® esiRNA - EHU136231 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN18950 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18950 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07192 from Sigma-Aldrich
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SCN11A siRNA (Human) - CRH7735 from Cohesion Biosciences
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SCN11A - MBS8226913 from MyBioSource
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shRNA set against Human SCN11A (NM_014139.2) - SHH402764 from Creative biogene
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shRNA set against Human SCN11A(NM_014139.2) - SHH221118 from Creative biogene
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Human SCN11A siRNA - orb268237 from Biorbyt
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SCN11A shRNA Plasmid (Human) - CHH7735 from Cohesion Biosciences
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SCN11A miRNA 3'UTR clone - MiUTR1H-09179 from Creative biogene
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