| Gene Symbol |
S100A1
|
| Entrez Gene |
6271
|
| Alt Symbol |
S100, S100-alpha, S100A
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
S100 calcium binding protein A1
|
| Other Description |
S-100 protein alpha chain|S-100 protein subunit alpha|S100 alpha|S100 calcium-binding protein A1|S100 protein, alpha polypeptide|protein S100-A1
|
| Swissprots |
B2R5D9 Q5T7Y3 P23297
|
| Accessions |
CAY39334 EAW53301 EAW53302 P23297 AB451316 BAG70130 AB451446 BAG70260 AK126904 AK312152 BAG35086 BC014392 AAH14392 BC035791 BC072006 BC094843 BT006938 AAP35584 X58079 CAA41107 NM_006271 NP_006262
|
| Function |
Weakly binds calcium but binds zinc very tightly- distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity. {ECO:0000269|PubMed:22399290}.
|
| Subcellular Location |
Cytoplasm.
|
| Tissue Specificity |
Highly prevalent in heart. Also found in lesser quantities in skeletal muscle and brain.
|
![Western Blot: S100A1 Overexpression Lysate (Adult Normal) [NBL1-15647] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for S100A1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/964_S100A1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-15647-img0002.jpg)