| Gene Symbol | Eed |
|---|---|
| Entrez Gene | 13626 |
| Alt Symbol | ENSMUSG00000039373, l(7)5Rn, l7Rn5, lusk |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | embryonic ectoderm development |
| Other Description | lethal, Chr 7, Rinchik 5|polycomb protein EED |
| Swissprots | P97462 Q921E6 |
| Accessions | EDL06770 EDL06771 Q921E6 AK016228 BAB30159 AK053947 AK077664 BAC36938 AK087924 AK131976 BAE20916 AK133890 BAE21915 AK213110 BC012966 AAH12966 BQ899891 CJ200028 U78103 AAB38319 U97675 AAC53302 XM_006507341 XP_006507404 XR_869658 XR_869659 NM_021876 NP_068676 |
| Function | Polycomb group (PcG) protein. Component of the PRC2/EED- EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark (By similarity). The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (By similarity). Genes repressed by the PRC2/EED-EZH2 complex include HOXA7, HOXB6 and HOXC8. Plays a role in X chromosome inactivation (XCI), in which one of the two X chromosomes in female mammals is transcriptionally silenced to equalize X-linked gene dosage with XY males. Required for stable maintenance of XCI in both embryonic and extraembryonic tissues. May prevent transcriptio |
| Subcellular Location | Nucleus. Chromosome. Note=Localizes to the inactive X chromosome in cells of the early embryo and in stem cells of the extraembryonic trophectoderm lineage. Recruitment to the inactive X-chromosome requires XIST. |
| Tissue Specificity | Expressed in brain, heart, kidney, liver, lung, muscle, ovary, spleen and testis. Expressed throughout the brain. {ECO:0000269|PubMed:17259173, ECO:0000269|PubMed:8805699, ECO:0000269|PubMed:9234727}. |