Eed

Gene Symbol Eed
Entrez Gene 13626
Alt Symbol ENSMUSG00000039373, l(7)5Rn, l7Rn5, lusk
Species Mouse
Gene Type protein-coding
Description embryonic ectoderm development
Other Description lethal, Chr 7, Rinchik 5|polycomb protein EED
Swissprots P97462 Q921E6
Accessions EDL06770 EDL06771 Q921E6 AK016228 BAB30159 AK053947 AK077664 BAC36938 AK087924 AK131976 BAE20916 AK133890 BAE21915 AK213110 BC012966 AAH12966 BQ899891 CJ200028 U78103 AAB38319 U97675 AAC53302 XM_006507341 XP_006507404 XR_869658 XR_869659 NM_021876 NP_068676
Function Polycomb group (PcG) protein. Component of the PRC2/EED- EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark (By similarity). The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (By similarity). Genes repressed by the PRC2/EED-EZH2 complex include HOXA7, HOXB6 and HOXC8. Plays a role in X chromosome inactivation (XCI), in which one of the two X chromosomes in female mammals is transcriptionally silenced to equalize X-linked gene dosage with XY males. Required for stable maintenance of XCI in both embryonic and extraembryonic tissues. May prevent transcriptio
Subcellular Location Nucleus. Chromosome. Note=Localizes to the inactive X chromosome in cells of the early embryo and in stem cells of the extraembryonic trophectoderm lineage. Recruitment to the inactive X-chromosome requires XIST.
Tissue Specificity Expressed in brain, heart, kidney, liver, lung, muscle, ovary, spleen and testis. Expressed throughout the brain. {ECO:0000269|PubMed:17259173, ECO:0000269|PubMed:8805699, ECO:0000269|PubMed:9234727}.

EED CRISPR/Cas9 KO Plasmid (m) - sc-420114 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

EED HDR Plasmid (m) - sc-420114-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

EED Double Nickase Plasmid (m) - sc-420114-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

EED Double Nickase Plasmid (m2) - sc-420114-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

EED CRISPR Activation Plasmid (m) - sc-420114-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

EED CRISPR Activation Plasmid (m2) - sc-420114-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

EED Lentiviral Activation Particles (m) - sc-420114-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

EED Lentiviral Activation Particles (m2) - sc-420114-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

EED siRNA (m) - sc-37824 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

EEDt shRNA Plasmid (m) - sc-37824-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

EEDt shRNA (m) Lentiviral Particles - sc-37824-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

MISSION® esiRNA - EMU178331 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN30440 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND30440 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

EED siRNA (Mouse) - CRM1138 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

EED - MBS8230807 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

shRNA set against Mouse EED (NM_021876.3) - SHH283249 from Creative biogene

Category siRNA
Species Reactivities Mouse

Mouse EED siRNA - orb280614 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

EED shRNA Plasmid (Mouse) - CHM1138 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Mouse
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