Eed

Gene Symbol Eed
Entrez Gene 13626
Alt Symbol ENSMUSG00000039373, l(7)5Rn, l7Rn5, lusk
Species Mouse
Gene Type protein-coding
Description embryonic ectoderm development
Other Description lethal, Chr 7, Rinchik 5|polycomb protein EED
Swissprots P97462 Q921E6
Accessions EDL06770 EDL06771 Q921E6 AK016228 BAB30159 AK053947 AK077664 BAC36938 AK087924 AK131976 BAE20916 AK133890 BAE21915 AK213110 BC012966 AAH12966 BQ899891 CJ200028 U78103 AAB38319 U97675 AAC53302 XM_006507341 XP_006507404 XR_869658 XR_869659 NM_021876 NP_068676
Function Polycomb group (PcG) protein. Component of the PRC2/EED- EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark (By similarity). The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (By similarity). Genes repressed by the PRC2/EED-EZH2 complex include HOXA7, HOXB6 and HOXC8. Plays a role in X chromosome inactivation (XCI), in which one of the two X chromosomes in female mammals is transcriptionally silenced to equalize X-linked gene dosage with XY males. Required for stable maintenance of XCI in both embryonic and extraembryonic tissues. May prevent transcriptio
Subcellular Location Nucleus. Chromosome. Note=Localizes to the inactive X chromosome in cells of the early embryo and in stem cells of the extraembryonic trophectoderm lineage. Recruitment to the inactive X-chromosome requires XIST.
Tissue Specificity Expressed in brain, heart, kidney, liver, lung, muscle, ovary, spleen and testis. Expressed throughout the brain. {ECO:0000269|PubMed:17259173, ECO:0000269|PubMed:8805699, ECO:0000269|PubMed:9234727}.

Recombinant Mouse Polycomb protein EED(Eed) - CSB-YP856362MO CSB-EP856362MO CSB-BP856362MO CSB-MP856362MO from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Mouse

Polycomb protein EED (Eed), Recombinant Protein - MBS1389017 from MyBioSource

Category Protein
Prices $1,220.00, $1,220.00, $1,440.00, $1,440.00, $1,975.00, $1,975.00, $2,440.00, $2,440.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Mouse

Recombinant Mouse EED Protein - EED-4997M from Creative Biomart

Category Protein
Source Mammalian Cells
Species Mouse

Mouse-Eed-Blocking-Peptide-Center - BP21210c from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg
Species Mouse

Mouse-Eed-Blocking-Peptide-N-term - BP21106a from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg
Species Mouse
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