Gene Symbol | MRC1 |
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Entrez Gene | 4360 |
Alt Symbol | CD206, CLEC13D, CLEC13DL, MMR, MRC1L1, bA541I19.1 |
Species | Human |
Gene Type | protein-coding |
Description | mannose receptor, C type 1 |
Other Description | C-type lectin domain family 13 member D|macrophage mannose receptor 1|macrophage mannose receptor 1-like protein 1|mannose receptor, C type 1-like 1 |
Swissprots | Q5VSJ2 Q5VSK2 A5PKW3 P22897 |
Accessions | AAA60389 ACA06020 CAH70733 CAH71176 CAI15339 CCQ43179 P22897 AK297044 BAG59571 AK308132 AK308167 AV659122 BC016003 BC142642 AAI42643 BC146838 AAI46839 BU198859 DC296466 DQ663787 ABG47462 J05550 AAA59868 X55635 NM_001009567 NM_002438 NP_002429 |
Function | Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains. Acts as phagocytic receptor for bacteria, fungi and other pathogens. |
Subcellular Location | Endosome membrane {ECO:0000269|PubMed:20035344}; Single-pass type I membrane protein {ECO:0000269|PubMed:20035344}. Cell membrane {ECO:0000269|PubMed:20035344}; Single-pass type I membrane protein {ECO:0000269|PubMed:20035344}. |
Top Pathways | Phagosome, Tuberculosis |
CD206 CRISPR/Cas9 KO Plasmid (h) - sc-400286 from Santa Cruz Biotechnology
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CD206 HDR Plasmid (h) - sc-400286-HDR from Santa Cruz Biotechnology
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CD206 Double Nickase Plasmid (h) - sc-400286-NIC from Santa Cruz Biotechnology
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CD206 Double Nickase Plasmid (h2) - sc-400286-NIC-2 from Santa Cruz Biotechnology
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CD206 CRISPR Activation Plasmid (h) - sc-400286-ACT from Santa Cruz Biotechnology
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CD206 CRISPR Activation Plasmid (h2) - sc-400286-ACT-2 from Santa Cruz Biotechnology
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CD206 Lentiviral Activation Particles (h) - sc-400286-LAC from Santa Cruz Biotechnology
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CD206 Lentiviral Activation Particles (h2) - sc-400286-LAC-2 from Santa Cruz Biotechnology
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CD206 siRNA (h) - sc-45360 from Santa Cruz Biotechnology
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CD206 shRNA Plasmid (h) - sc-45360-SH from Santa Cruz Biotechnology
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CD206 shRNA (h) Lentiviral Particles - sc-45360-V from Santa Cruz Biotechnology
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MMR/CD206/Mannose Receptor RNAi - H00414308-R02 from Novus Biologicals
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MMR/CD206/Mannose Receptor RNAi - H00004360-R02 from Novus Biologicals
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MISSION® esiRNA - EHU126811 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN14525 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14525 from Sigma-Aldrich
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MRC1 siRNA (Human) - CRH2963 from Cohesion Biosciences
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shRNA set against Human MRC1 (NM_002438.2) - SHH344196 from Creative biogene
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MRC1 shRNA Plasmid (Human) - CHH2963 from Cohesion Biosciences
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MRC1 miRNA 3'UTR clone - MiUTR1H-06411 from Creative biogene
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