Gene Symbol | FGF21 |
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Entrez Gene | 26291 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | fibroblast growth factor 21 |
Other Description | - |
Swissprots | Q8N683 Q9NSA1 |
Accessions | ABI75345 CAC41219 CBL54507 CBY65805 CBY65875 EAW52401 EAW52402 Q9NSA1 AB021975 BAA99415 AY359086 AAQ89444 BC018404 AAH18404 DQ891786 ABM82712 DQ894970 ABM85896 XM_005258731 XP_005258788 NM_019113 NP_061986 |
Function | Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity requires the presence of KLB. {ECO:0000269|PubMed:15902306, ECO:0000269|PubMed:17623664}. |
Subcellular Location | Secreted {ECO:0000305}. |
Top Pathways | Melanoma, MAPK signaling pathway, PI3K-Akt signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton |
FGF-21 CRISPR/Cas9 KO Plasmid (h) - sc-401193 from Santa Cruz Biotechnology
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FGF-21 HDR Plasmid (h) - sc-401193-HDR from Santa Cruz Biotechnology
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FGF-21 Double Nickase Plasmid (h) - sc-401193-NIC from Santa Cruz Biotechnology
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FGF-21 Double Nickase Plasmid (h2) - sc-401193-NIC-2 from Santa Cruz Biotechnology
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FGF-21 CRISPR Activation Plasmid (h) - sc-401193-ACT from Santa Cruz Biotechnology
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FGF-21 CRISPR Activation Plasmid (h2) - sc-401193-ACT-2 from Santa Cruz Biotechnology
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FGF-21 Lentiviral Activation Particles (h) - sc-401193-LAC from Santa Cruz Biotechnology
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FGF-21 Lentiviral Activation Particles (h2) - sc-401193-LAC-2 from Santa Cruz Biotechnology
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FGF-21 siRNA (h) - sc-39484 from Santa Cruz Biotechnology
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FGF-21 shRNA Plasmid (h) - sc-39484-SH from Santa Cruz Biotechnology
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FGF-21 shRNA (h) Lentiviral Particles - sc-39484-V from Santa Cruz Biotechnology
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FGF-21 RNAi - H00026291-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN8657 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8657 from Sigma-Aldrich
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FGF21 siRNA (Human) - CRH8810 from Cohesion Biosciences
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FGF21 - MBS8223943 from MyBioSource
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shRNA set against Human FGF21 (NM_019113.2) - SHH294505 from Creative biogene
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shRNA set against Human FGF21(NM_019113.2) - SHH057557 from Creative biogene
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FGF21 shRNA Plasmid (Human) - CHH8810 from Cohesion Biosciences
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FGF21 miRNA 3'UTR clone - MiUTR1H-03629 from Creative biogene
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