PTPRC

Gene Symbol PTPRC
Entrez Gene 5788
Alt Symbol B220, CD45, CD45R, GP180, L-CA, LCA, LY5, T200
Species Human
Gene Type protein-coding
Description protein tyrosine phosphatase, receptor type, C
Other Description CD45 antigen|T200 glycoprotein|T200 leukocyte common antigen|protein tyrosine phosphatase, receptor type, c polypeptide|receptor-type tyrosine-protein phosphatase C
Swissprots Q9H0Y6 P08575 Q16614 A8K7W6
Accessions AAA59497 AAD15273 AAG26082 AAM12758 AAS46922 AAS46930 AAS46938 AAS46946 AAS46954 AAS46962 CBU30438 CBU83087 EAW91300 EAW91301 EAW91302 EAW91303 P08575 AA403163 AA904360 AK130573 AK292131 BAF84820 AK299986 BAG61807 AK303539 BAG64565 AK307635 AK308217 AK310898 AY429565 AY429566 AY567999 AAS75254 BC014239 AAH14239 BC017863 AAH17863 BC031525 BC121086 AAI21087 BC121087 AAI21088 BC127656 AAI27657 BC127657 AAI27658 BC148257 AAI48258 BC169206 BC169207 BM791051 DA670254 DA819314 DA948670 Y00062 CAA68269 Y00638 CAA68669 XM_006711472 XP_006711535 XM_006711473 XP_006711536 XM_006711474 XP_006711537 NM_001267798 NP_001254727 NM_002838 NP_002829 NM_080921 NP_563578 NR_052021 NM_080922
Function Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity). {ECO:0000250}.
Subcellular Location Membrane {ECO:0000269|PubMed:12676959}; Single-pass type I membrane protein {ECO:0000269|PubMed:12676959}. Membrane raft {ECO:0000269|PubMed:12676959}. Note=Colocalized with DPP4 in membrane rafts.
Top Pathways T cell receptor signaling pathway, Cell adhesion molecules (CAMs), Primary immunodeficiency, Fc gamma R-mediated phagocytosis

CD45 (D9M8I) XP ® Rabbit mAb (PE Conjugate) - 14579 from Cell Signaling Technology

Prices $329.00
Sizes 100 µl (50 tests)
Host Rabbit
Clonality Monoclonal
Clone D9M8I
Flow cytometric analysis of 293T cells (blue) and Jurkat cells (green) using CD45 (D9M8I) XP ® Rabbit mAb (PE Conjugate).

CD45 (D9M8I) XP ® Rabbit mAb - 13917 from Cell Signaling Technology

Prices $109.00, $282.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D9M8I
Western blot analysis of extracts from various cell lines using CD45 (D9M8I) XP ® Rabbit mAb (upper) and β-Actin (D6A8) Rabbit mAb #8457 (lower).

CD45 (136-4B5) Mouse mAb - 3575 from Cell Signaling Technology

Host Mouse
Clonality Monoclonal
Clone 136-4B5
Immunohistochemical analysis of paraffin-embedded human tonsil using CD45 (136-4B5) Mouse mAb.

CD45 (B-8) - sc-28369 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CD45 (B-8): sc-28369. Immunoperoxidase staining of formalin fixed, paraffin-embedded human peripheral blood lymphocytes showing membrane localization.

CD45 (F10-89-4) - sc-52490 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CD45 (F10-89-4): sc-52490. Western blot analysis of CD45 expression in GA-10 (A) and Ramos (B) whole cell lysates.

CD45 (H-230) - sc-25590 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
CD45 (H-230): sc-25590. Western blot analysis of CD45 expression in Jurkat (A) and CCRF-CEM (B) whole cell lysates.

CD45 (N-19) - sc-1123 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Western blot analysis of CD45 expression in Jurkat (A,D), BJAB (B) and WEHI-231 (C) whole cell lysates. Antibodies tested include CD45 (35-Z6): sc-1178 (AC) and CD45 (N-19): sc-1123 (D).

CD45 (OX1) - sc-53045 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CD45 (OX1): sc-53045. Indirect FCM analysis of rat peripheral blood leukocytes stained with CD45 (OX1), followed by PE-conjugated goat anti-mouse IgG: sc-3738. Black line histogram represents the isotype control, normal mouse IgG<sub>1</sub>: sc-3877.

CD45 (T29/33) - sc-18901 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CD45 (T29/33): sc-18901. Western blot analysis of CD45 expression in Jurkat (A), CCRF-CEM (B) and HL-60 (C) whole cell lysates.

CD45 (YAML 501.4) - sc-65344 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rat
Clonality Monoclonal
CD45 (YAML 501.4): sc-65344. Indirect FCM analysis of human peripheral blood leukocytes stained with CD45 (YAML 501.4), followed by PE-conjugated goat anti-mouse IgG: sc-3738. Black line histogram represents the isotype control, normal rat IgG2a: sc-3883

CD45 (YTH24.5) - sc-59070 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rat
Clonality Monoclonal
CD45 (YTH24.5): sc-59070. Western blot analysis of CD45 expression in NAMALWA (A), Ramos (B), AML-193 (C) and HL-60 (D) whole cell lysates.

CD45 (YTH80.103) - sc-59071 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rat
Clonality Monoclonal
CD45 (YTH80.103): sc-59071. Western blot analysis of CD45 expression in U-698-M whole cell lysate.

CD45 (351C5) - sc-53201 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CD45 (351C5): sc-53201. Indirect FCM analysis of human peripheral blood leukocytes stained with CD45 (351C5), followed by PE-conjugated goat anti-mouse IgM: sc-3767. Black line histogram represents the isotype control, normal mouse IgM: sc-3881

CD45 (35-Z6) - sc-1178 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CD45 (35-Z6): sc-1178. Western blot analysis of CD45 expression in Jurkat (A) and BJAB (B) whole cell lysates.

CD45 (2D-1) - sc-1187 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CD45 (2D-1): sc-1187. Western blot analysis of CD45 expression in CCRF-CEM (A) and Jurkat (B) whole cell lysates.

CD45 (2B11) - sc-20056 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CD45 (2B11) PE: sc-20056 PE. FCM analysis of human peripheral blood leukocytes. Black line histogram represents the isotype control, normal mouse IgG<sub>1</sub>: sc-2866.

CD45 (158-4D3) - sc-52386 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CD45 (158-4D3): sc-52386. Indirect FCM analysis of human peripheral blood leukocytes stained with CD45 (158-4D3), followed by PE-conjugated goat anti-mouse IgG: sc-3738. Black line histogram represents the isotype control, normal mouse IgG<sub>2a</sub>: sc-3878.

CD45 (3H1363) - sc-70699 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rat
Clonality Monoclonal
CD45 (3H1363): sc-70699. Western blot analysis of CD45 expression in GA-10 (A), human PBL (B) and Ramos (C) whole cell lysates.

CD45 (6A230) - sc-70696 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CD45 (6A230): sc-70696. Western blot analysis of CD45 expression in human platelet extract (A), HL-60 (B) and THP-1 (C) whole cell lysates.

CD45RA (4KB5) - sc-20057 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CD45RA (4KB5) FITC: sc-20057 FITC. FCM analysis of human peripheral blood leukocytes. Quadrant markers were set based on the isotype control, normal mouse IgG<sub>1</sub>: sc-2855.

CD45RA (F8-11-13) - sc-19665 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CD45RA (F8-11-13): sc-19665. Western blot analysis of CD45RA expression in AML-193 (A) and NAMALWA (B) whole cell lysates.

CD45RA (HI100) - sc-19664 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CD45RA (HI100) FITC: sc-19664 FITC. FCM analysis of GA-10 cells. Black line histogram represents the isotype control, normal mouse IgG<sub>2b</sub>: sc-2857.

CD45RA (3H1433) - sc-70704 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal

CD45RB (BRA11) - sc-66202 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CD45RB (BRA11): sc-66202. Indirect FCM analysis of human peripheral blood leukocytes stained with CD45RB (BRA11), followed by PE-conjugated goat anti-mouse IgG: sc-3738. Black line histogram represents the isotype control, normal mouse IgG1: sc-3877

CD45RB (PD7/26) - sc-53203 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CD45RB (PD7/26): sc-53203. Indirect FCM analysis of human peripheral blood leukocytes stained with CD45RB (PD7/26), followed by PE-conjugated goat anti-mouse IgG<sub>1</sub>: sc-3764. Black line histogram represents the isotype control, normal mouse IgG<sub>1</sub>: sc-3877.
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