PTPRC

Gene Symbol	PTPRC
Entrez Gene	5788
Alt Symbol	B220, CD45, CD45R, GP180, L-CA, LCA, LY5, T200
Species	Human
Gene Type	protein-coding
Description	protein tyrosine phosphatase, receptor type, C
Other Description	CD45 antigen|T200 glycoprotein|T200 leukocyte common antigen|protein tyrosine phosphatase, receptor type, c polypeptide|receptor-type tyrosine-protein phosphatase C
Swissprots	Q9H0Y6 P08575 Q16614 A8K7W6
Accessions	AAA59497 AAD15273 AAG26082 AAM12758 AAS46922 AAS46930 AAS46938 AAS46946 AAS46954 AAS46962 CBU30438 CBU83087 EAW91300 EAW91301 EAW91302 EAW91303 P08575 AA403163 AA904360 AK130573 AK292131 BAF84820 AK299986 BAG61807 AK303539 BAG64565 AK307635 AK308217 AK310898 AY429565 AY429566 AY567999 AAS75254 BC014239 AAH14239 BC017863 AAH17863 BC031525 BC121086 AAI21087 BC121087 AAI21088 BC127656 AAI27657 BC127657 AAI27658 BC148257 AAI48258 BC169206 BC169207 BM791051 DA670254 DA819314 DA948670 Y00062 CAA68269 Y00638 CAA68669 XM_006711472 XP_006711535 XM_006711473 XP_006711536 XM_006711474 XP_006711537 NM_001267798 NP_001254727 NM_002838 NP_002829 NM_080921 NP_563578 NR_052021 NM_080922
Function	Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity). {ECO:0000250}.
Subcellular Location	Membrane {ECO:0000269|PubMed:12676959}; Single-pass type I membrane protein {ECO:0000269|PubMed:12676959}. Membrane raft {ECO:0000269|PubMed:12676959}. Note=Colocalized with DPP4 in membrane rafts.
Top Pathways	T cell receptor signaling pathway, Cell adhesion molecules (CAMs), Primary immunodeficiency, Fc gamma R-mediated phagocytosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PTPRC 293 Cell Lysate - 400942 from ABBIOTEC Category Cell Lysate Prices $672.00 Sizes 100 µg

CD45 Overexpression Lysate (Native) - NBL1-14981 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

PTPRC Over-expression Lysate Product - GWB-FE65C4 from Genway Biotech Category Cell Lysate Prices $756.00 Sizes 100 µg Species Human

Human CD45 / PTPRC HEK293 Cell Lysate (WB positive control) - 10086-H02HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Panoply™ Human PTPRC Knockdown Stable Cell Line - CSC-DC012714 from Creative biogene Category Cell Line Species Human

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