PTPRC

Gene Symbol PTPRC
Entrez Gene 5788
Alt Symbol B220, CD45, CD45R, GP180, L-CA, LCA, LY5, T200
Species Human
Gene Type protein-coding
Description protein tyrosine phosphatase, receptor type, C
Other Description CD45 antigen|T200 glycoprotein|T200 leukocyte common antigen|protein tyrosine phosphatase, receptor type, c polypeptide|receptor-type tyrosine-protein phosphatase C
Swissprots Q9H0Y6 P08575 Q16614 A8K7W6
Accessions AAA59497 AAD15273 AAG26082 AAM12758 AAS46922 AAS46930 AAS46938 AAS46946 AAS46954 AAS46962 CBU30438 CBU83087 EAW91300 EAW91301 EAW91302 EAW91303 P08575 AA403163 AA904360 AK130573 AK292131 BAF84820 AK299986 BAG61807 AK303539 BAG64565 AK307635 AK308217 AK310898 AY429565 AY429566 AY567999 AAS75254 BC014239 AAH14239 BC017863 AAH17863 BC031525 BC121086 AAI21087 BC121087 AAI21088 BC127656 AAI27657 BC127657 AAI27658 BC148257 AAI48258 BC169206 BC169207 BM791051 DA670254 DA819314 DA948670 Y00062 CAA68269 Y00638 CAA68669 XM_006711472 XP_006711535 XM_006711473 XP_006711536 XM_006711474 XP_006711537 NM_001267798 NP_001254727 NM_002838 NP_002829 NM_080921 NP_563578 NR_052021 NM_080922
Function Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity). {ECO:0000250}.
Subcellular Location Membrane {ECO:0000269|PubMed:12676959}; Single-pass type I membrane protein {ECO:0000269|PubMed:12676959}. Membrane raft {ECO:0000269|PubMed:12676959}. Note=Colocalized with DPP4 in membrane rafts.
Top Pathways T cell receptor signaling pathway, Cell adhesion molecules (CAMs), Primary immunodeficiency, Fc gamma R-mediated phagocytosis

Active human CD45 protein fragment - ab94517 from Abcam

Category Protein
Prices $302.00
Sizes 10 µg
Source Baculovirus infected sf9 cells
Species Human
ab94517 in a Sample Kinase Activity Plot.

Active human CD45 protein fragment - ab42584 from Abcam

Category Protein
Prices $284.00
Sizes 10 µg
Source Baculovirus infected sf9 cells
Species Human

Human CD45 peptide - ab17550 from Abcam

Category Peptide
Prices $181.00
Sizes 100 µg
ab10559 rabbit polyclonal to CD45 (1/500) with secondary goat anti-rabbit IgG ab6721 (1/5000). Expected molecular weight: 147 kDa. WB exposure time: 1min 30sec Lanes 1 to 10: 20 µ g of cell lysate per lane Lanes 6 to 10: ab17550 CD45 blocking peptide used at 1 µ g/ml Lane 1: HeLa Nuclear Extract ( ab10559 ) Lane 2: HeLa Whole Cell Lysate ( ab10559 ) Lane 3: A431 Whole Cell Lysate ( ab10559 ) Lane 4: Jurkat Whole Cell Lysate ( ab10559 ) Lane 5: HEK293 Whole Cell Lysate ( ab10559 ) Lane 6: HeLa Nuclear Extract ( ab10559 + ab17550) Lane 7: HeLa Whole Cell Lysate ( ab10559 + ab17550) Lane 8: A431 Whole Cell Lysate ( ab10559 + ab17550) Lane 9: Jurkat Whole Cell Lysate ( ab10559 + ab17550) Lane 10: HEK293 Whole Cell Lysate ( ab10559 + ab17550) Binding of

Human CD45 peptide - ab17553 from Abcam

Category Peptide
Prices $181.00
Sizes 100 µg
Species Human
All lanes : Anti-CD45 antibody ( ab10558 ) at 1/500 dilution Lane 1 : Jurkat Whole Cell Lysate Lane 2 : Jurkat Whole Cell Lysate with Human CD45 peptide (ab17553) Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG H&L (HRP) ( ab6721 ) at 1/5000 dilution

Human CD45 protein fragment - ab159285 from Abcam

Category Protein
Prices $402.00
Sizes 10 µg
Source Wheat germ
Species Human
ab159285 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Human CD45 protein fragment - ab159286 from Abcam

Category Protein
Prices $402.00
Sizes 10 µg
Source Wheat germ
Species Human
ab159286 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Human CD45 protein fragment - ab177717 from Abcam

Category Protein
Prices $301.00
Sizes 20 µg
Source E. coli
Species Human
15% SDS-PAGE analysis of ab177717 (3μg).

Human CD45 protein fragment - ab195062 from Abcam

Category Protein
Prices $199.00
Sizes 2 µg
Source Mammalian
Species Human
SDS-PAGE analysis of 2 μg ab195062.

Human CD45 protein fragment - ab195108 from Abcam

Category Protein
Prices $155.00
Sizes 10 µg
Source Mammalian
Species Human
SDS-PAGE analysis of 2 μg ab195108.

CD45 Antibody Blocking Peptide - LS-E1170 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

CD45 Antibody Blocking Peptide - LS-E3989 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

CD45 Antibody Blocking Peptide - LS-E21617 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

CD45 Antibody Blocking Peptide - LS-E29647 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 50 µg

Recombinant Human CD45 Protein - H00005788-Q01 from Novus Biologicals

Category Protein
Prices $369.00, $529.00
Sizes 10 µg, 25 µg
Source Wheat Germ
Species Human

CD45 Recombinant Protein - H00005788-Q02 from Novus Biologicals

Category Protein
Prices $369.00
Sizes 10 µg
Species Human

CD45 Peptide - P0590 from Novus Biologicals

Category Peptide
Species Human

PTPRC-Antibody-N-term-Blocking-peptide - BP11708a from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

CD45-Antibody-C-term-Blocking-Peptide - BP1620a from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

Recombinant Human CD45, CF - 1430-CD-050 from R&D Systems

Category Protein
Source Mouse myeloma cell line, NS0-derived, Gln24-Lys575, with a C-terminal 6-His tag

CD45 Protein (OPPA01381) - OPPA01381 from Aviva Systems Biology

Category Protein
Prices $315.00
Sizes 2 µg
Source E. Coli

Human CD45 Fc tag protein - orb82903 from Biorbyt

Category Protein
Prices $400.00, $612.00
Sizes 50 μg, 100 μg
Source Human
Species Human
SDS-PAGE analysis of Human CD45 Fc tag protein

Human CD45 protein - orb246778 from Biorbyt

Category Protein
Prices $213.00, $408.00, $680.00, $1,122.00, $1,777.00
Sizes 10 μg, 50 μg, 200 μg, 500 μg, 1 mg
Species Human

Human PTPRC Protein - abx068771 from Abbexa

Category Protein
Source E.coli
Species Human

CD45 / LCA (1031-1251, His-tag) - AR51397PU-N from Acris Antibodies

Category Protein
Prices $790.00
Sizes 100 µg
Source E. coli
Species Human
CD45 / LCA

CD45 / LCA (1031-1251, His-tag) - AR51397PU-S from Acris Antibodies

Category Protein
Prices $340.00
Sizes 20 µg
Source E. coli
Species Human
CD45 / LCA
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