Gene Symbol | USP9X |
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Entrez Gene | 8239 |
Alt Symbol | DFFRX, FAF, FAM, MRX99 |
Species | Human |
Gene Type | protein-coding |
Description | ubiquitin specific peptidase 9, X-linked |
Other Description | Drosophila fat facets related, X-linked|deubiquitinating enzyme FAF-X|fat facets in mammals|fat facets protein related, X-linked|fat facets protein-related, X-linked|hFAM|probable ubiquitin carboxyl-terminal hydrolase FAF-X|ubiquitin specific protease 9, X chromosome (fat facets-like Drosophila)|ubiquitin thioesterase FAF-X|ubiquitin thiolesterase FAF-X|ubiquitin-specific processing protease FAF-X|ubiquitin-specific protease 9, X chromosome|ubiquitin-specific-processing protease FAF-X |
Swissprots | Q8WWT3 Q8WX12 O75550 Q93008 |
Accessions | EAW59406 EAW59407 EAW59408 EAW59409 EAW59410 EAW59411 EAW59412 Q93008 AA261797 AB209666 BAD92903 AF070645 AAC25395 AJ012078 AK294828 BAG57940 AW183065 BC014792 BC046205 AAH46205 BC054861 BC063645 AAH63645 BC172429 AAI72429 BE925861 BX956755 CD619095 DA854185 HG512500 X98296 CAA66942 XM_005272675 XP_005272732 XM_005272676 XP_005272733 NM_001039590 NP_001034679 NM_001039591 NP_001034680 NM_004652 NM_021906 |
Function | Deubiquitinase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important role regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. Essential component of TGF-beta/BMP signaling cascade. Regulates chromosome alignment and segregation in mitosis by regulating the localization of BIRC5/survivin to mitotic centromeres. Specifically hydrolyzes both 'Lys-29'- and 'Lys-33'-linked polyubiquitins chains. Specifically deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33. Involved in axonal growth and neuronal cell migration. {ECO:0000269|PubMed:16322459, ECO:0000269|PubMed:18254724, ECO:0000269|PubMed:19135894, ECO:0000269|PubMed:24607389}. |
Subcellular Location | Cytoplasm. Cell projection, growth cone. |
Tissue Specificity | Widely expressed in embryonic and adult tissues. |
Human USP9x peptide - ab20617 from Abcam
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Human USP9x peptide - ab20618 from Abcam
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Human USP9x protein fragment - ab152844 from Abcam
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Recombinant Human His6-USP9x Isoform 2, CF - ab188692 from Abcam
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USP9X / FAM Antibody Blocking Peptide - LS-E21707 from LifeSpan Bioscience
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USP9X / FAM Antibody Blocking Peptide - LS-E26770 from LifeSpan Bioscience
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Recombinant Human USP9x Protein - H00008239-Q01 from Novus Biologicals
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Recombinant Human His6-USP9x Isoform 2, CF - E-552-025 from R&D Systems
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USP9X - H00008239-Q01-10 from Acris Antibodies
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USP9X - H00008239-Q01-25 from Acris Antibodies
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Recombinant Human USP9X, GST-tagged - USP9X-184H from Creative Biomart
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Recombinant Human USP9X, Met&His-tagged - USP9X-658H from Creative Biomart
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Recombinant Human Probable ubiquitin carboxyl-terminal hydrolase FAF-X(USP9X) ,partial - CSB-YP856610HU CSB-EP856610HU CSB-BP856610HU CSB-MP856610HU from Cusabio
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Human USP9x full length protein - ab205998 from Abcam
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Recombinant Human His6-USP9x Isoform 2 Protein, CF - E-552 from R&D Systems
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Probable ubiquitin carboxyl-terminal hydrolase FAF-X (USP9X), partial, Recombinant Protein - MBS1321678 from MyBioSource
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USP9X Peptide, Human - M34GP17202H from Creative Peptides
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Recombinant Human His6-USP9x Isoform 2 Protein, CF - E-552 from Novus Biologicals
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