USP9X

Gene Symbol	USP9X
Entrez Gene	8239
Alt Symbol	DFFRX, FAF, FAM, MRX99
Species	Human
Gene Type	protein-coding
Description	ubiquitin specific peptidase 9, X-linked
Other Description	Drosophila fat facets related, X-linked|deubiquitinating enzyme FAF-X|fat facets in mammals|fat facets protein related, X-linked|fat facets protein-related, X-linked|hFAM|probable ubiquitin carboxyl-terminal hydrolase FAF-X|ubiquitin specific protease 9, X chromosome (fat facets-like Drosophila)|ubiquitin thioesterase FAF-X|ubiquitin thiolesterase FAF-X|ubiquitin-specific processing protease FAF-X|ubiquitin-specific protease 9, X chromosome|ubiquitin-specific-processing protease FAF-X
Swissprots	Q8WWT3 Q8WX12 O75550 Q93008
Accessions	EAW59406 EAW59407 EAW59408 EAW59409 EAW59410 EAW59411 EAW59412 Q93008 AA261797 AB209666 BAD92903 AF070645 AAC25395 AJ012078 AK294828 BAG57940 AW183065 BC014792 BC046205 AAH46205 BC054861 BC063645 AAH63645 BC172429 AAI72429 BE925861 BX956755 CD619095 DA854185 HG512500 X98296 CAA66942 XM_005272675 XP_005272732 XM_005272676 XP_005272733 NM_001039590 NP_001034679 NM_001039591 NP_001034680 NM_004652 NM_021906
Function	Deubiquitinase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important role regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. Essential component of TGF-beta/BMP signaling cascade. Regulates chromosome alignment and segregation in mitosis by regulating the localization of BIRC5/survivin to mitotic centromeres. Specifically hydrolyzes both 'Lys-29'- and 'Lys-33'-linked polyubiquitins chains. Specifically deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33. Involved in axonal growth and neuronal cell migration. {ECO:0000269|PubMed:16322459, ECO:0000269|PubMed:18254724, ECO:0000269|PubMed:19135894, ECO:0000269|PubMed:24607389}.
Subcellular Location	Cytoplasm. Cell projection, growth cone.
Tissue Specificity	Widely expressed in embryonic and adult tissues.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® USP9X siRNA I - 6308 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

USP9X CRISPR/Cas9 KO Plasmid (h) - sc-402285 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

USP9X HDR Plasmid (h) - sc-402285-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

USP9X Double Nickase Plasmid (h) - sc-402285-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

USP9X Double Nickase Plasmid (h2) - sc-402285-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

USP9X CRISPR Activation Plasmid (h) - sc-402285-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

USP9X CRISPR Activation Plasmid (h2) - sc-402285-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

USP9X Lentiviral Activation Particles (h) - sc-402285-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

USP9X Lentiviral Activation Particles (h2) - sc-402285-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

USP9X siRNA (h) - sc-63197 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

USP9X shRNA Plasmid (h) - sc-63197-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

USP9X shRNA (h) Lentiviral Particles - sc-63197-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

USP9x RNAi - H00008239-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

USP9x RNAi - H00008239-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU159431 from Sigma-Aldrich Category siRNA

CompoZr® Knockout ZFN Kit - CKOZFN22607 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22607 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

USP9X siRNA (Human) - CRH5410 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

USP9X - MBS8227109 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human USP9X (NM_001039590.2) - SHH441820 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human USP9X(NM_001039590.2) - SHL118952 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human USP9X(NM_001039591.2) - SHL119052 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human USP9X(NM_001039590.2) - SHL119078 from Creative biogene Category siRNA Species Reactivities Human

Human USP9X siRNA - orb265912 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

USP9X shRNA Plasmid (Human) - CHH5410 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

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