Gene Symbol | USP9X |
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Entrez Gene | 8239 |
Alt Symbol | DFFRX, FAF, FAM, MRX99 |
Species | Human |
Gene Type | protein-coding |
Description | ubiquitin specific peptidase 9, X-linked |
Other Description | Drosophila fat facets related, X-linked|deubiquitinating enzyme FAF-X|fat facets in mammals|fat facets protein related, X-linked|fat facets protein-related, X-linked|hFAM|probable ubiquitin carboxyl-terminal hydrolase FAF-X|ubiquitin specific protease 9, X chromosome (fat facets-like Drosophila)|ubiquitin thioesterase FAF-X|ubiquitin thiolesterase FAF-X|ubiquitin-specific processing protease FAF-X|ubiquitin-specific protease 9, X chromosome|ubiquitin-specific-processing protease FAF-X |
Swissprots | Q8WWT3 Q8WX12 O75550 Q93008 |
Accessions | EAW59406 EAW59407 EAW59408 EAW59409 EAW59410 EAW59411 EAW59412 Q93008 AA261797 AB209666 BAD92903 AF070645 AAC25395 AJ012078 AK294828 BAG57940 AW183065 BC014792 BC046205 AAH46205 BC054861 BC063645 AAH63645 BC172429 AAI72429 BE925861 BX956755 CD619095 DA854185 HG512500 X98296 CAA66942 XM_005272675 XP_005272732 XM_005272676 XP_005272733 NM_001039590 NP_001034679 NM_001039591 NP_001034680 NM_004652 NM_021906 |
Function | Deubiquitinase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important role regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. Essential component of TGF-beta/BMP signaling cascade. Regulates chromosome alignment and segregation in mitosis by regulating the localization of BIRC5/survivin to mitotic centromeres. Specifically hydrolyzes both 'Lys-29'- and 'Lys-33'-linked polyubiquitins chains. Specifically deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33. Involved in axonal growth and neuronal cell migration. {ECO:0000269|PubMed:16322459, ECO:0000269|PubMed:18254724, ECO:0000269|PubMed:19135894, ECO:0000269|PubMed:24607389}. |
Subcellular Location | Cytoplasm. Cell projection, growth cone. |
Tissue Specificity | Widely expressed in embryonic and adult tissues. |
USP9X (D4Y7W) Rabbit mAb - 14898 from Cell Signaling Technology
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USP9X Antibody - 5751 from Cell Signaling Technology
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USP9 (5G-02) - sc-100628 from Santa Cruz Biotechnology
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USP9X/Y (G-20) - sc-55424 from Santa Cruz Biotechnology
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USP9X/Y (K-17) - sc-55425 from Santa Cruz Biotechnology
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USP9X (P-20) - sc-55427 from Santa Cruz Biotechnology
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USP9X (M-20) - sc-55426 from Santa Cruz Biotechnology
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USP9X/Y (E-12) - sc-365353 from Santa Cruz Biotechnology
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USP9X/Y (G-10) - sc-373818 from Santa Cruz Biotechnology
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USP9X/Y (H-300) - sc-134916 from Santa Cruz Biotechnology
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Anti-USP9x antibody - ab19879 from Abcam
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Anti-USP9x antibody - ab26334 from Abcam
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Anti-USP9x antibody - ab56461 from Abcam
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Anti-USP9x antibody - ab99343 from Abcam
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Anti-USP9x antibody - ab111046 from Abcam
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Anti-USP9x antibody [EPR13809(B)] - N-terminal - ab180191 from Abcam
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Anti-USP9X / FAM Antibody (clone 2G7) - LS-C174599 from LifeSpan Bioscience
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Anti-USP9X / FAM Antibody (aa1150-1300, Biotin) - LS-C143431 from LifeSpan Bioscience
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Anti-USP9X / FAM Antibody (aa1150-1300, DY650) - LS-C143432 from LifeSpan Bioscience
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Anti-USP9X / FAM Antibody (aa1150-1300, HRP) - LS-C143434 from LifeSpan Bioscience
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Anti-USP9X / FAM Antibody (aa1150-1300, DY488) - LS-C143433 from LifeSpan Bioscience
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Anti-USP9X / FAM Antibody (aa1150-1300, DY550) - LS-C143435 from LifeSpan Bioscience
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Anti-USP9X / FAM Antibody - LS-C191377 from LifeSpan Bioscience
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Anti-USP9X / FAM Antibody (aa2497-2547) - LS-C288160 from LifeSpan Bioscience
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Anti-USP9X / FAM Antibody (aa625-675) - LS-C288161 from LifeSpan Bioscience
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