| Gene Symbol | PSMB4 |
|---|---|
| Entrez Gene | 5692 |
| Alt Symbol | HN3, HsN3, PROS-26, PROS26 |
| Species | Human |
| Gene Type | protein-coding |
| Description | proteasome (prosome, macropain) subunit, beta type, 4 |
| Other Description | 26 kDa prosomal protein|hsBPROS26|macropain beta chain|multicatalytic endopeptidase complex beta chain|proteasome beta chain|proteasome chain 3|proteasome subunit HsN3|proteasome subunit beta type-4|proteasome subunit, beta type, 4 |
| Swissprots | P31148 Q6IBI4 Q969L6 B2R9L3 Q5SZS5 P28070 |
| Accessions | EAW53442 P28070 AK294149 BAG57474 AK313825 BAG36560 BC000331 BC008314 BC010088 BC010098 BC011768 BC012168 BC017307 BC017451 BC017486 BT006917 AAP35563 CR456820 CAG33101 D26600 BAA05647 DQ890748 ABM81674 DQ892020 ABM82946 DQ895212 ABM86138 S71381 AAB31085 NM_002796 NP_002787 |
| Function | The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Mediates the lipopolysaccharide-induced signal macrophage proteasome (By similarity). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. {ECO:0000250, ECO:0000269|PubMed:12097147}. |
| Subcellular Location | Cytoplasm {ECO:0000255|PROSITE- ProRule:PRU00809}. Nucleus {ECO:0000250}. |
| Top Pathways | Proteasome |