Gene Symbol | PSMB4 |
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Entrez Gene | 5692 |
Alt Symbol | HN3, HsN3, PROS-26, PROS26 |
Species | Human |
Gene Type | protein-coding |
Description | proteasome (prosome, macropain) subunit, beta type, 4 |
Other Description | 26 kDa prosomal protein|hsBPROS26|macropain beta chain|multicatalytic endopeptidase complex beta chain|proteasome beta chain|proteasome chain 3|proteasome subunit HsN3|proteasome subunit beta type-4|proteasome subunit, beta type, 4 |
Swissprots | P31148 Q6IBI4 Q969L6 B2R9L3 Q5SZS5 P28070 |
Accessions | EAW53442 P28070 AK294149 BAG57474 AK313825 BAG36560 BC000331 BC008314 BC010088 BC010098 BC011768 BC012168 BC017307 BC017451 BC017486 BT006917 AAP35563 CR456820 CAG33101 D26600 BAA05647 DQ890748 ABM81674 DQ892020 ABM82946 DQ895212 ABM86138 S71381 AAB31085 NM_002796 NP_002787 |
Function | The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Mediates the lipopolysaccharide-induced signal macrophage proteasome (By similarity). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. {ECO:0000250, ECO:0000269|PubMed:12097147}. |
Subcellular Location | Cytoplasm {ECO:0000255|PROSITE- ProRule:PRU00809}. Nucleus {ECO:0000250}. |
Top Pathways | Proteasome |
PSMB4 (H-3) - sc-390878 from Santa Cruz Biotechnology
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PSMB4 (C-18) - sc-74864 from Santa Cruz Biotechnology
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PSMB4 (LX-1) - sc-100454 from Santa Cruz Biotechnology
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Anti-Proteasome subunit beta type 4 (phospho S249) antibody - ab90623 from Abcam
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Anti-Proteasome subunit beta type 4 antibody - ab55628 from Abcam
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Anti-Proteasome subunit beta type 4 antibody - ab192372 from Abcam
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Anti-Proteasome subunit beta type 4 antibody - ab37651 from Abcam
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Anti-Proteasome subunit beta type 4 antibody [EPR9396] - ab137067 from Abcam
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Anti-Proteasome subunit beta type 4 antibody [EPR9397] - ab137087 from Abcam
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Anti-PSMB4 Antibody (clone 2C9) - LS-C173306 from LifeSpan Bioscience
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Anti-PSMB4 Antibody (FITC) - LS-C183265 from LifeSpan Bioscience
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Anti-PSMB4 Antibody (clone 6F10) - LS-C173340 from LifeSpan Bioscience
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Anti-PSMB4 Antibody (clone 1B6) - LS-C173305 from LifeSpan Bioscience
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Anti-PSMB4 Antibody (Biotin) - LS-C183266 from LifeSpan Bioscience
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Anti-PSMB4 Antibody - LS-C190017 from LifeSpan Bioscience
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Anti-PSMB4 Antibody (clone 7B4) - LS-C173272 from LifeSpan Bioscience
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Anti-PSMB4 Antibody (FITC) - LS-C316808 from LifeSpan Bioscience
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Anti-PSMB4 Antibody (HRP) - LS-C316810 from LifeSpan Bioscience
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Anti-PSMB4 Antibody (FITC) - LS-C211071 from LifeSpan Bioscience
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Anti-PSMB4 Antibody (clone 5B5) - LS-C173271 from LifeSpan Bioscience
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Anti-PSMB4 Antibody (Biotin) - LS-C211073 from LifeSpan Bioscience
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Anti-PSMB4 Antibody - LS-C211070 from LifeSpan Bioscience
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Anti-PSMB4 Antibody (HRP) - LS-C211069 from LifeSpan Bioscience
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Anti-PSMB4 Antibody (Biotin) - LS-C316811 from LifeSpan Bioscience
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Anti-PSMB4 Antibody (clone 1F8) - LS-C173349 from LifeSpan Bioscience
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