USP17L2

Gene Symbol	USP17L2
Entrez Gene	377630
Alt Symbol	DUB-3, DUB3, USP17
Species	Human
Gene Type	protein-coding
Description	ubiquitin specific peptidase 17-like family member 2
Other Description	deubiquitinating enzyme 17-like protein 2|deubiquitinating enzyme 3|deubiquitinating protein 3|ubiquitin carboxyl-terminal hydrolase 17|ubiquitin carboxyl-terminal hydrolase 17-like protein 2|ubiquitin specific peptidase 17-like 2|ubiquitin thioesterase 17-like protein 2|ubiquitin thiolesterase 17-like protein 2|ubiquitin-specific-processing protease 17-like protein 2
Swissprots	Q6R6M4
Accessions	Q6R6M4 AY509884 AAR91701 BC156290 AAI56291 BC157073 AAI57074 NM_201402 NP_958804
Function	Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Regulates cell proliferation by deubiquitinating and inhibiting RCE1 thereby controlling the small GTPases NRAS and HRAS localization and activation. In parallel, mediates deubiquitination of CDC25A, preventing CDC25A degradation by the proteasome during the G1/S and G2/M phases promoting cell-cycle progression. Also regulates cell proliferation and apoptosis through deubiquitination of SUDS3 a regulator of histone deacetylation. Through activation of the Rho family GTPases RAC1A, CDC42 and RHOA, regulates cell migration. Through the cleavage of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains of the cytoplasmic innate immune receptors DDX58 and IFIH1 stimulates the cellular response to viral infection. {ECO:0000269|PubMed:14699124, ECO:0000269|PubMed:17109758, ECO:0000269|PubMed:19188362, ECO:0000269|PubMed:20147298, ECO:0000269|PubMed:20228808, ECO:0000269|PubM
Subcellular Location	Nucleus. Endoplasmic reticulum.
Tissue Specificity	Broadly expressed. {ECO:0000269|PubMed:14699124}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

USP17L2 (C-19) - sc-102499 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

USP17L4 (N-17) - sc-102759 from Santa Cruz Biotechnology Prices $279.00 Sizes 100 µg/ml Host Rabbit Clonality Polyclonal

Anti-Dub3 antibody - ab188236 from Abcam Host Rabbit Clonality Polyclonal

Anti-Dub3 antibody - ab129931 from Abcam Prices $370.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-USP17L2 / DUB3 Antibody (aa475-503, AP) - LS-C242481 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-USP17L2 / DUB3 Antibody (aa475-503, FITC) - LS-C242485 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-USP17L2 / DUB3 Antibody (aa475-503, Biotin) - LS-C242484 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-USP17L2 / DUB3 Antibody (aa475-503, APC) - LS-C242482 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-USP17L2 / DUB3 Antibody (aa475-503, PE) - LS-C242487 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-USP17L2 / DUB3 Antibody (aa475-503, Azide-free, HRP) - LS-C247201 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-USP17L2 / DUB3 Antibody (aa431-531) - LS-C307310 from LifeSpan Bioscience Prices $455.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-USP17L2 / DUB3 Antibody (aa475-503) - LS-C326228 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-USP17L2 / DUB3 Antibody (aa481-530) - LS-C205429 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-USP17L2 / DUB3 Antibody (aa371-420) - LS-C116937 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-USP17L2 / DUB3 Antibody (aa496-524) - LS-C160396 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-USP17L2 / DUB3 Antibody (aa476-503) - LS-C160470 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

USP17 Antibody - NBP2-13508 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Dub3 Antibody - NBP1-79745 from Novus Biologicals Prices $139.00, $329.00 Sizes 20 µl, 100 µl Host Rabbit Clonality Polyclonal

Dub3 Antibody (3G12) - H00377630-M01 from Novus Biologicals Prices $359.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 3G12

Dub3 Antibody - H00377630-A01 from Novus Biologicals Host Mouse Clonality Polyclonal

Monoclonal Anti-DUB3 antibody produced in mouse - WH0377630M1 from Sigma-Aldrich Prices $347.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 3G12

ANTI-USP17L2 (C-TERM) antibody produced in rabbit - SAB1303963 from Sigma-Aldrich Prices $326.50 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-USP17L2 antibody produced in rabbit - SAB2107373 from Sigma-Aldrich Prices $341.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

USP17L2 antibody - middle region (ARP59279_P050) - ARP59279_P050 from Aviva Systems Biology Prices $289.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

USP17L2-Antibody-C-term - AP16721b from Abgent, a WuXi AppTec company Prices $95.00, $265.00 Sizes 80 µl, 400 µl Host Rabbit Clonality Polyclonal

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