| Gene Symbol |
USP17L2
|
| Entrez Gene |
377630
|
| Alt Symbol |
DUB-3, DUB3, USP17
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ubiquitin specific peptidase 17-like family member 2
|
| Other Description |
deubiquitinating enzyme 17-like protein 2|deubiquitinating enzyme 3|deubiquitinating protein 3|ubiquitin carboxyl-terminal hydrolase 17|ubiquitin carboxyl-terminal hydrolase 17-like protein 2|ubiquitin specific peptidase 17-like 2|ubiquitin thioesterase 17-like protein 2|ubiquitin thiolesterase 17-like protein 2|ubiquitin-specific-processing protease 17-like protein 2
|
| Swissprots |
Q6R6M4
|
| Accessions |
Q6R6M4 AY509884 AAR91701 BC156290 AAI56291 BC157073 AAI57074 NM_201402 NP_958804
|
| Function |
Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Regulates cell proliferation by deubiquitinating and inhibiting RCE1 thereby controlling the small GTPases NRAS and HRAS localization and activation. In parallel, mediates deubiquitination of CDC25A, preventing CDC25A degradation by the proteasome during the G1/S and G2/M phases promoting cell-cycle progression. Also regulates cell proliferation and apoptosis through deubiquitination of SUDS3 a regulator of histone deacetylation. Through activation of the Rho family GTPases RAC1A, CDC42 and RHOA, regulates cell migration. Through the cleavage of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains of the cytoplasmic innate immune receptors DDX58 and IFIH1 stimulates the cellular response to viral infection. {ECO:0000269|PubMed:14699124, ECO:0000269|PubMed:17109758, ECO:0000269|PubMed:19188362, ECO:0000269|PubMed:20147298, ECO:0000269|PubMed:20228808, ECO:0000269|PubM
|
| Subcellular Location |
Nucleus. Endoplasmic reticulum.
|
| Tissue Specificity |
Broadly expressed. {ECO:0000269|PubMed:14699124}.
|