USP17L2

Gene Symbol	USP17L2
Entrez Gene	377630
Alt Symbol	DUB-3, DUB3, USP17
Species	Human
Gene Type	protein-coding
Description	ubiquitin specific peptidase 17-like family member 2
Other Description	deubiquitinating enzyme 17-like protein 2|deubiquitinating enzyme 3|deubiquitinating protein 3|ubiquitin carboxyl-terminal hydrolase 17|ubiquitin carboxyl-terminal hydrolase 17-like protein 2|ubiquitin specific peptidase 17-like 2|ubiquitin thioesterase 17-like protein 2|ubiquitin thiolesterase 17-like protein 2|ubiquitin-specific-processing protease 17-like protein 2
Swissprots	Q6R6M4
Accessions	Q6R6M4 AY509884 AAR91701 BC156290 AAI56291 BC157073 AAI57074 NM_201402 NP_958804
Function	Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Regulates cell proliferation by deubiquitinating and inhibiting RCE1 thereby controlling the small GTPases NRAS and HRAS localization and activation. In parallel, mediates deubiquitination of CDC25A, preventing CDC25A degradation by the proteasome during the G1/S and G2/M phases promoting cell-cycle progression. Also regulates cell proliferation and apoptosis through deubiquitination of SUDS3 a regulator of histone deacetylation. Through activation of the Rho family GTPases RAC1A, CDC42 and RHOA, regulates cell migration. Through the cleavage of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains of the cytoplasmic innate immune receptors DDX58 and IFIH1 stimulates the cellular response to viral infection. {ECO:0000269|PubMed:14699124, ECO:0000269|PubMed:17109758, ECO:0000269|PubMed:19188362, ECO:0000269|PubMed:20147298, ECO:0000269|PubMed:20228808, ECO:0000269|PubM
Subcellular Location	Nucleus. Endoplasmic reticulum.
Tissue Specificity	Broadly expressed. {ECO:0000269|PubMed:14699124}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Dub3 protein fragment - ab112436 from Abcam Category Protein Source Wheat germ Species Human

Human USP17 full length protein - ab166471 from Abcam Category Protein Source Wheat germ Species Human

USP17L2 / DUB3 Antibody Blocking Peptide - LS-E4412 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

USP17L2 / DUB3 Antibody Blocking Peptide - LS-E7860 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

USP17L2 / DUB3 Antibody Blocking Peptide - LS-E21681 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Dub3 Protein - H00377630-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

USP17L2-Antibody-C-term-Blocking-Peptide - BP16721b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

USP17L2 Blocking Peptide - 33R-3136 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

USP17L2 / DUB3 - H00377630-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

USP17L2 / DUB3 - H00377630-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Recombinant Human USP17L2 - USP17L2-28070TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Human Ubiquitin carboxyl-terminal hydrolase 17-like protein 2(USP17L2) - CSB-YP750926HU CSB-EP750926HU CSB-BP750926HU CSB-MP750926HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

USP17L2 Peptide, Human - M34GP17155H from Creative Peptides Category Peptide Source Synthetic. Species Human

DUB3 fusion protein - Ag24012 from Proteintech Group Category Protein Source E. coli -derived, PET28a Species Human

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