USP30

Gene Symbol	USP30
Entrez Gene	84749
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	ubiquitin specific peptidase 30
Other Description	deubiquitinating enzyme 30|ub-specific protease 30|ubiquitin carboxyl-terminal hydrolase 30|ubiquitin specific protease 30|ubiquitin thioesterase 30|ubiquitin thiolesterase 30|ubiquitin-specific protease 30|ubiquitin-specific-processing protease 30
Swissprots	Q8WTU7 Q9BSS3 Q70CQ3 Q96JX4
Accessions	CAE89969 EAW97842 EAW97843 EAW97844 Q70CQ3 AA856774 AI867665 AJ586136 CAE51936 AK027820 BAB55392 AK097830 BAG53537 AL834278 BC004868 AAH04868 BC022094 AAH22094 BG149730 BX095894 CN367077 DQ893401 ABM84327 DQ896783 ABM87782 HY127211 XM_005253962 XP_005254019 XM_005253963 XP_005254020 XM_005253965 XP_005254022 XM_006719653 XP_006719716 XM_011538894 XP_011537196 NM_001301175 NP_001288104 NM_032663 NP_116052
Function	Deubiquitinating enzyme tethered to the mitochondrial outer membrane that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PARK2): hydrolyzes ubiquitin attached by parkin on target proteins, such as RHOT1/MIRO1 and TOMM20, thereby blocking parkin's ability to drive mitophagy (PubMed:18287522, PubMed:24896179, PubMed:25527291, PubMed:25621951). Preferentially cleaves 'Lys-6'- and 'Lys-11'- linked polyubiquitin chains, 2 types of linkage that participate to mitophagic signaling (PubMed:25621951). Does not cleave efficiently polyubiquitin phosphorylated at 'Ser-65' (PubMed:25527291). Acts as negative regulator of mitochondrial fusion by mediating deubiquitination of MFN1 and MFN2 (By similarity). {ECO:0000250|UniProtKB:Q3UN04, ECO:0000269|PubMed:18287522, ECO:0000269|PubMed:24896179, ECO:0000269|PubMed:25527291, ECO:0000269|PubMed:25621951}.
Subcellular Location	Mitochondrion outer membrane {ECO:0000269|PubMed:18287522, ECO:0000269|PubMed:24896179}.
Tissue Specificity	Expressed in skeletal muscle, pancreas, liver and kidney. {ECO:0000269|PubMed:14715245}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human USP30 full length protein - ab164652 from Abcam Category Protein Source Wheat germ Species Human

Human USP30 protein fragment - ab164653 from Abcam Category Protein Source Wheat germ Species Human

USP30 Antibody Blocking Peptide - LS-E3529 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

USP30 Antibody Blocking Peptide - LS-E18096 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human USP30 Protein - H00084749-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

Recombinant Human USP30 Protein - H00084749-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

USP30-Antibody-N-term-Blocking-Peptide - BP14725a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human USP30 protein (N-SUMO Tag) - orb139847 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Baculovirus-Insect Cells Species Human

USP30 peptide - orb218683 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

USP30 Blocking Peptide - 33R-8332 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

USP30 Blocking Peptide - abx064014 from Abbexa Category Peptide Species Human, Mouse, Rat, Dog, Monkey

USP30 - H00084749-P01-02 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Source in vitro transl. Species Human

USP30 - H00084749-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

USP30 - H00084749-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

USP30 fusion protein - Ag7620 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human USP30, SUMO tagged - USP30-8654H from Creative Biomart Category Protein Source Baculovirus-Insect cells Species Human

Recombinant Human USP30, His-tagged - USP30-3626H from Creative Biomart Category Protein Source E.coli Species Human

Human Ubiquitin specific peptidase 30 / USP30 Protein (SUMO Tag) - 14548-H21B-50 from Sino Biological Category Protein Prices $178.00, $178.00 Sizes 50 µg, 100 µg Source Baculovirus-Insect Cells Species Human

USP30 Blocking Peptide - CBP2820 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Dog, Monkey

Recombinant Human Ubiquitin carboxyl-terminal hydrolase 30(USP30) - CSB-YP765106HU CSB-EP765106HU CSB-BP765106HU CSB-MP765106HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human His6-USP30 Protein, CF - E-582 from R&D Systems Category Protein Prices $365.00 Sizes 50 µg Source Spodoptera frugiperda , Sf 21 (baculovirus)-derived Contains a C-terminal 6-His tag, Thr57 - Glu517 Accession # Q70CQ3 Species Human

USP30 Recombinant Protein Antigen - NBP1-81914PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

USP30 Peptide, Human - M34GP17173H from Creative Peptides Category Peptide Source Synthetic. Species Human

Human Ubiquitin specific peptidase 30 / USP30 Protein (SUMO Tag) - 14548-H21B from ABclonal Category Protein Prices $178.00, $298.00 Sizes 50 µg, 100 µg Source Baculovirus-Insect Cells Species Human

Recombinant Human OTULIN Protein, His-tagged - OTULIN-357H from Creative Biomart Category Protein Source Bacteria Species Human

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