USP30

Gene Symbol	USP30
Entrez Gene	84749
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	ubiquitin specific peptidase 30
Other Description	deubiquitinating enzyme 30|ub-specific protease 30|ubiquitin carboxyl-terminal hydrolase 30|ubiquitin specific protease 30|ubiquitin thioesterase 30|ubiquitin thiolesterase 30|ubiquitin-specific protease 30|ubiquitin-specific-processing protease 30
Swissprots	Q8WTU7 Q9BSS3 Q70CQ3 Q96JX4
Accessions	CAE89969 EAW97842 EAW97843 EAW97844 Q70CQ3 AA856774 AI867665 AJ586136 CAE51936 AK027820 BAB55392 AK097830 BAG53537 AL834278 BC004868 AAH04868 BC022094 AAH22094 BG149730 BX095894 CN367077 DQ893401 ABM84327 DQ896783 ABM87782 HY127211 XM_005253962 XP_005254019 XM_005253963 XP_005254020 XM_005253965 XP_005254022 XM_006719653 XP_006719716 XM_011538894 XP_011537196 NM_001301175 NP_001288104 NM_032663 NP_116052
Function	Deubiquitinating enzyme tethered to the mitochondrial outer membrane that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PARK2): hydrolyzes ubiquitin attached by parkin on target proteins, such as RHOT1/MIRO1 and TOMM20, thereby blocking parkin's ability to drive mitophagy (PubMed:18287522, PubMed:24896179, PubMed:25527291, PubMed:25621951). Preferentially cleaves 'Lys-6'- and 'Lys-11'- linked polyubiquitin chains, 2 types of linkage that participate to mitophagic signaling (PubMed:25621951). Does not cleave efficiently polyubiquitin phosphorylated at 'Ser-65' (PubMed:25527291). Acts as negative regulator of mitochondrial fusion by mediating deubiquitination of MFN1 and MFN2 (By similarity). {ECO:0000250|UniProtKB:Q3UN04, ECO:0000269|PubMed:18287522, ECO:0000269|PubMed:24896179, ECO:0000269|PubMed:25527291, ECO:0000269|PubMed:25621951}.
Subcellular Location	Mitochondrion outer membrane {ECO:0000269|PubMed:18287522, ECO:0000269|PubMed:24896179}.
Tissue Specificity	Expressed in skeletal muscle, pancreas, liver and kidney. {ECO:0000269|PubMed:14715245}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

USP30 (V-14) - sc-109455 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-USP30 antibody - ab74368 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-USP30 antibody - ab123696 from Abcam Prices $370.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-USP30 antibody - C-terminal - ab197167 from Abcam Prices $370.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-USP30 Antibody (aa156-185, AP) - LS-C273181 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-USP30 Antibody (aa156-185, APC) - LS-C273182 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-USP30 Antibody (aa156-185, Biotin) - LS-C273183 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-USP30 Antibody (aa156-185, FITC) - LS-C273184 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-USP30 Antibody (aa156-185, Azide-free, HRP) - LS-C273185 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-USP30 Antibody (aa156-185, PE) - LS-C273186 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-USP30 Antibody (aa155-185) - LS-C326233 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-USP30 Antibody (aa141-190) - LS-C117026 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-USP30 Antibody (aa156-185) - LS-C160473 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-USP30 Antibody (aa31-80) - LS-C120444 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-USP30 Antibody - LS-C343773 from LifeSpan Bioscience Prices $405.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

USP30 Antibody - NBP1-79335 from Novus Biologicals Prices $329.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

USP30 Antibody - NBP1-81914 from Novus Biologicals Prices $129.00, $419.00 Sizes 25 µl, 100 µl Host Rabbit Clonality Polyclonal

Anti-USP30 antibody produced in rabbit - HPA016952 from Sigma-Aldrich Prices $429.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-USP30, N-Terminal antibody produced in rabbit - SAB4503385 from Sigma-Aldrich Prices $335.50 Sizes 100 µg Host Rabbit Clonality Polyclonal

USP30 antibody - middle region (ARP50098_P050) - ARP50098_P050 from Aviva Systems Biology Prices $289.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

USP30-Antibody-N-term - AP14725a from Abgent, a WuXi AppTec company Prices $95.00, $265.00 Sizes 80 µl, 400 µl Host Rabbit Clonality Polyclonal

USP30 Antibody - N-terminal region (OAAB11056) - OAAB11056 from Aviva Systems Biology Prices $289.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

USP30 Antibody (OAAF04408) - OAAF04408 from Aviva Systems Biology Prices $289.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

USP30 antibody - orb128901 from Biorbyt Prices $85.00, $255.00, $425.00 Sizes 25 μg (Trial Size), 100 μg, 200 μg Host Rabbit Clonality Polyclonal

USP30 antibody - orb195021 from Biorbyt Prices $417.00, $536.00 Sizes 50 μl, 100 μl Host Rabbit Clonality Polyclonal

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