USP30

Gene Symbol USP30
Entrez Gene 84749
Alt Symbol -
Species Human
Gene Type protein-coding
Description ubiquitin specific peptidase 30
Other Description deubiquitinating enzyme 30|ub-specific protease 30|ubiquitin carboxyl-terminal hydrolase 30|ubiquitin specific protease 30|ubiquitin thioesterase 30|ubiquitin thiolesterase 30|ubiquitin-specific protease 30|ubiquitin-specific-processing protease 30
Swissprots Q8WTU7 Q9BSS3 Q70CQ3 Q96JX4
Accessions CAE89969 EAW97842 EAW97843 EAW97844 Q70CQ3 AA856774 AI867665 AJ586136 CAE51936 AK027820 BAB55392 AK097830 BAG53537 AL834278 BC004868 AAH04868 BC022094 AAH22094 BG149730 BX095894 CN367077 DQ893401 ABM84327 DQ896783 ABM87782 HY127211 XM_005253962 XP_005254019 XM_005253963 XP_005254020 XM_005253965 XP_005254022 XM_006719653 XP_006719716 XM_011538894 XP_011537196 NM_001301175 NP_001288104 NM_032663 NP_116052
Function Deubiquitinating enzyme tethered to the mitochondrial outer membrane that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PARK2): hydrolyzes ubiquitin attached by parkin on target proteins, such as RHOT1/MIRO1 and TOMM20, thereby blocking parkin's ability to drive mitophagy (PubMed:18287522, PubMed:24896179, PubMed:25527291, PubMed:25621951). Preferentially cleaves 'Lys-6'- and 'Lys-11'- linked polyubiquitin chains, 2 types of linkage that participate to mitophagic signaling (PubMed:25621951). Does not cleave efficiently polyubiquitin phosphorylated at 'Ser-65' (PubMed:25527291). Acts as negative regulator of mitochondrial fusion by mediating deubiquitination of MFN1 and MFN2 (By similarity). {ECO:0000250|UniProtKB:Q3UN04, ECO:0000269|PubMed:18287522, ECO:0000269|PubMed:24896179, ECO:0000269|PubMed:25527291, ECO:0000269|PubMed:25621951}.
Subcellular Location Mitochondrion outer membrane {ECO:0000269|PubMed:18287522, ECO:0000269|PubMed:24896179}.
Tissue Specificity Expressed in skeletal muscle, pancreas, liver and kidney. {ECO:0000269|PubMed:14715245}.

USP30 CRISPR/Cas9 KO Plasmid (h) - sc-407851 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

USP30 HDR Plasmid (h) - sc-407851-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

USP30 Double Nickase Plasmid (h) - sc-407851-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

USP30 Double Nickase Plasmid (h2) - sc-407851-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

USP30 CRISPR Activation Plasmid (h) - sc-407851-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

USP30 CRISPR Activation Plasmid (h2) - sc-407851-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

USP30 Lentiviral Activation Particles (h) - sc-407851-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

USP30 Lentiviral Activation Particles (h2) - sc-407851-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

USP30 siRNA (h) - sc-96007 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

USP30 shRNA Plasmid (h) - sc-96007-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

USP30 shRNA (h) Lentiviral Particles - sc-96007-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU155291 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN22579 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22579 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR03813 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr03813

USP30 siRNA (Human) - CRJ3609 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

USP30 - MBS8200582 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human USP30 (NM_032663.3) - SHH441468 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human USP30(NM_032663.3) - SHL117390 from Creative biogene

Category siRNA
Species Reactivities Human

Human USP30 siRNA - orb274110 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

USP30 shRNA Plasmid (Human) - CHJ3609 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

USP30 miRNA 3'UTR clone - MiUTR1H-11058 from Creative biogene

Species Reactivities Human
Search more