| Gene Symbol |
PTPRN2
|
| Entrez Gene |
5799
|
| Alt Symbol |
IA-2beta, IAR, ICAAR, PTPRP, R-PTP-N2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
protein tyrosine phosphatase, receptor type, N polypeptide 2
|
| Other Description |
IAR/receptor-like protein-tyrosine phosphatase|islet cell autoantigen-related protein|phogrin|protein tyrosine phosphatase receptor pi|receptor-type tyrosine-protein phosphatase N2|tyrosine phosphatase IA-2 beta
|
| Swissprots |
E9PC57 Q92932 Q9Y4I6 Q8N4I5 Q92662 Q9Y4F8
|
| Accessions |
EAX04577 EAX04578 Q92932 AB002385 BAA20841 AB383870 BAG09726 AF007555 AAB63600 AL157451 CAB75665 AW292950 BC034040 AAH34040 BC071570 AAH71570 BG059906 CB850986 DB498958 DQ892399 ABM83325 DR003669 EU176514 ABW03315 U65065 AAC51643 U66702 AAC50742 U81561 AAB68603 XM_011516445 XP_011514747 XM_011516446 XP_011514748 XM_011516447 XP_011514749 XM_011516448 XP_011514750 XM_011516449 XP_011514751 NM_001308267 NP_001295196 NM_001308268 NP_001295197 NM_002847 NP_002838 NM_130842 NP_570857 NM_130843 NP_570858
|
| Function |
Implicated in development of nervous system and pancreatic endocrine cells. {ECO:0000269|PubMed:8798755, ECO:0000269|PubMed:8878534}.
|
| Subcellular Location |
Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
|
| Tissue Specificity |
Highest levels in brain and pancreas. Lower levels in trachea, prostate, stomach and spinal chord.
|
| Top Pathways |
Type I diabetes mellitus
|