| Gene Symbol |
Rbbp5
|
| Entrez Gene |
213464
|
| Alt Symbol |
4933411J24Rik, C330016J05
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
retinoblastoma binding protein 5
|
| Other Description |
RBBP-5|retinoblastoma-binding protein 5
|
| Swissprots |
Q3TBL4 Q8BX09 Q6PAP0 Q6PFC2 Q3U3G1
|
| Accessions |
EDL39675 EDL39676 Q8BX09 AK016773 BAB30420 AK049247 BAC33635 AK154782 BAE32825 AK170520 AK171177 BAE42295 AK179022 AK183478 AK188299 AK195903 AK210604 AK211089 AK211823 BC030892 BC057632 AAH57632 BC060186 AAH60186 BY193756 CV562303 XM_006529357 XP_006529420 XM_006529358 XP_006529421 XM_006529359 XP_006529422 NM_172517 NP_766105
|
| Function |
As part of the MLL1/MLL complex, involved in mono-, di- and trimethylation at 'Lys-4' of histone H3. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid. Does not affect ES cell self-renewal. {ECO:0000269|PubMed:21335234}.
|
| Subcellular Location |
Nucleus {ECO:0000250}.
|