Gene Symbol | Rbbp5 |
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Entrez Gene | 213464 |
Alt Symbol | 4933411J24Rik, C330016J05 |
Species | Mouse |
Gene Type | protein-coding |
Description | retinoblastoma binding protein 5 |
Other Description | RBBP-5|retinoblastoma-binding protein 5 |
Swissprots | Q3TBL4 Q8BX09 Q6PAP0 Q6PFC2 Q3U3G1 |
Accessions | EDL39675 EDL39676 Q8BX09 AK016773 BAB30420 AK049247 BAC33635 AK154782 BAE32825 AK170520 AK171177 BAE42295 AK179022 AK183478 AK188299 AK195903 AK210604 AK211089 AK211823 BC030892 BC057632 AAH57632 BC060186 AAH60186 BY193756 CV562303 XM_006529357 XP_006529420 XM_006529358 XP_006529421 XM_006529359 XP_006529422 NM_172517 NP_766105 |
Function | As part of the MLL1/MLL complex, involved in mono-, di- and trimethylation at 'Lys-4' of histone H3. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid. Does not affect ES cell self-renewal. {ECO:0000269|PubMed:21335234}. |
Subcellular Location | Nucleus {ECO:0000250}. |
RBQ-3 CRISPR/Cas9 KO Plasmid (m) - sc-431875 from Santa Cruz Biotechnology
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RBQ-3 HDR Plasmid (m) - sc-431875-HDR from Santa Cruz Biotechnology
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RBQ-3 Double Nickase Plasmid (m) - sc-431875-NIC from Santa Cruz Biotechnology
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RBQ-3 Double Nickase Plasmid (m2) - sc-431875-NIC-2 from Santa Cruz Biotechnology
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RBQ-3 CRISPR Activation Plasmid (m) - sc-431875-ACT from Santa Cruz Biotechnology
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RBQ-3 CRISPR Activation Plasmid (m2) - sc-431875-ACT-2 from Santa Cruz Biotechnology
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RBQ-3 Lentiviral Activation Particles (m) - sc-431875-LAC from Santa Cruz Biotechnology
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RBQ-3 Lentiviral Activation Particles (m2) - sc-431875-LAC-2 from Santa Cruz Biotechnology
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RBQ-3 siRNA (m) - sc-76374 from Santa Cruz Biotechnology
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RBQ-3 shRNA Plasmid (m) - sc-76374-SH from Santa Cruz Biotechnology
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RBQ-3 shRNA (m) Lentiviral Particles - sc-76374-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU005691 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN39948 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND39948 from Sigma-Aldrich
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RBBP5 siRNA (Mouse) - CRN1838 from Cohesion Biosciences
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RBBP5 - MBS8231068 from MyBioSource
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shRNA set against Mouse RBBP5 (NM_172517.2) - SHH390352 from Creative biogene
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shRNA set against Mouse Rbbp5(NM_172517.2) - SHR167664 from Creative biogene
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RBBP5 shRNA Plasmid (Mouse) - CHN1838 from Cohesion Biosciences
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RBBP5 miRNA 3'UTR clone - MiUTR1M-09964 from Creative biogene
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