| Gene Symbol | CHRM3 |
|---|---|
| Entrez Gene | 1131 |
| Alt Symbol | EGBRS, HM3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | cholinergic receptor, muscarinic 3 |
| Other Description | acetylcholine receptor, muscarinic 3|m3 muscarinic receptor|muscarinic acetylcholine receptor M3 |
| Swissprots | Q9HB60 Q5VXY2 P20309 Q4QRI3 Q0VAJ8 |
| Accessions | AAA70337 BAA94480 CAA33337 CAF85818 EAW70076 EAW70077 EAW70078 P20309 AF279779 AAG30036 AF385589 AAK68114 AF498917 AAM18940 AK056349 AK074575 AK095715 BC096844 AAH96844 BC121026 AAI21027 BC121027 BX099030 EU832135 ACE87485 EU832228 ACE86798 XM_005273032 XP_005273089 XM_005273034 XP_005273091 XM_011544041 XP_011542343 XM_011544042 XP_011542344 XM_011544043 XP_011542345 XM_011544044 XP_011542346 XM_011544045 XP_011542347 XM_011544046 XP_011542348 XM_011544047 XP_011542349 NM_000740 NP_000731 |
| Function | The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. {ECO:0000269|PubMed:7565628}. |
| Subcellular Location | Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. |
| Top Pathways | Calcium signaling pathway, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Regulation of actin cytoskeleton |