Gene Symbol | CHRM3 |
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Entrez Gene | 1131 |
Alt Symbol | EGBRS, HM3 |
Species | Human |
Gene Type | protein-coding |
Description | cholinergic receptor, muscarinic 3 |
Other Description | acetylcholine receptor, muscarinic 3|m3 muscarinic receptor|muscarinic acetylcholine receptor M3 |
Swissprots | Q9HB60 Q5VXY2 P20309 Q4QRI3 Q0VAJ8 |
Accessions | AAA70337 BAA94480 CAA33337 CAF85818 EAW70076 EAW70077 EAW70078 P20309 AF279779 AAG30036 AF385589 AAK68114 AF498917 AAM18940 AK056349 AK074575 AK095715 BC096844 AAH96844 BC121026 AAI21027 BC121027 BX099030 EU832135 ACE87485 EU832228 ACE86798 XM_005273032 XP_005273089 XM_005273034 XP_005273091 XM_011544041 XP_011542343 XM_011544042 XP_011542344 XM_011544043 XP_011542345 XM_011544044 XP_011542346 XM_011544045 XP_011542347 XM_011544046 XP_011542348 XM_011544047 XP_011542349 NM_000740 NP_000731 |
Function | The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. {ECO:0000269|PubMed:7565628}. |
Subcellular Location | Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. |
Top Pathways | Calcium signaling pathway, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Regulation of actin cytoskeleton |
mAChR M3 CRISPR/Cas9 KO Plasmid (h) - sc-400829 from Santa Cruz Biotechnology
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mAChR M3 HDR Plasmid (h) - sc-400829-HDR from Santa Cruz Biotechnology
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mAChR M3 Double Nickase Plasmid (h) - sc-400829-NIC from Santa Cruz Biotechnology
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mAChR M3 Double Nickase Plasmid (h2) - sc-400829-NIC-2 from Santa Cruz Biotechnology
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mAChR M3 CRISPR Activation Plasmid (h) - sc-400829-ACT from Santa Cruz Biotechnology
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mAChR M3 CRISPR Activation Plasmid (h2) - sc-400829-ACT-2 from Santa Cruz Biotechnology
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mAChR M3 Lentiviral Activation Particles (h) - sc-400829-LAC from Santa Cruz Biotechnology
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mAChR M3 Lentiviral Activation Particles (h2) - sc-400829-LAC-2 from Santa Cruz Biotechnology
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mAChR M3 siRNA (h) - sc-35833 from Santa Cruz Biotechnology
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mAChR M3 shRNA Plasmid (h) - sc-35833-SH from Santa Cruz Biotechnology
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mAChR M3 shRNA (h) Lentiviral Particles - sc-35833-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU006541 from Sigma-Aldrich
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MISSION® esiRNA - EHU027151 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6093 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6093 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02114 from Sigma-Aldrich
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CHRM3 siRNA (Human) - CRH0808 from Cohesion Biosciences
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Muscarinic Acetylcholine Receptor M3/CHRM3 RNAi - H00001131-R02 from Novus Biologicals
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CHRM3 - MBS8226416 from MyBioSource
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shRNA set against Human CHRM3(NM_000740.2) - SHG176569 from Creative biogene
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Human CHRM3 siRNA - orb261310 from Biorbyt
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CHRM3 shRNA Plasmid (Human) - CHH0808 from Cohesion Biosciences
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CHRM3 miRNA 3'UTR clone - MiUTR1H-02139 from Creative biogene
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