| Gene Symbol |
ACER1
|
| Entrez Gene |
125981
|
| Alt Symbol |
ALKCDase1, ASAH3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
alkaline ceramidase 1
|
| Other Description |
N-acylsphingosine amidohydrolase (alkaline ceramidase) 3|N-acylsphingosine amidohydrolase 3|acylsphingosine deacylase 3|alkCDase 1|alkaline CDase 1
|
| Swissprots |
Q8TDN7
|
| Accessions |
EAW69104 EAW69105 Q8TDN7 AF347024 AAL83822 BC112122 AAI12123 BC112124 AAI12125 CU449837 HG510303 XM_011527673 XP_011525975 NM_133492 NP_597999
|
| Function |
Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 8.0. Has a highly restricted substrate specificity for the natural stereoisomer of ceramide with D-erythro-sphingosine but not D-ribo- phytosphingosine or D-erythro-dihydrosphingosine as a backbone. May have a role in regulating the levels of bioactive lipids ceramide and sphingosine 1-phosphate, as well as complex sphingolipids (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
|
| Tissue Specificity |
Mainly expressed in epidermis. {ECO:0000269|PubMed:16477081}.
|
| Top Pathways |
Sphingolipid signaling pathway, Sphingolipid metabolism
|