ACER1

Gene Symbol	ACER1
Entrez Gene	125981
Alt Symbol	ALKCDase1, ASAH3
Species	Human
Gene Type	protein-coding
Description	alkaline ceramidase 1
Other Description	N-acylsphingosine amidohydrolase (alkaline ceramidase) 3|N-acylsphingosine amidohydrolase 3|acylsphingosine deacylase 3|alkCDase 1|alkaline CDase 1
Swissprots	Q8TDN7
Accessions	EAW69104 EAW69105 Q8TDN7 AF347024 AAL83822 BC112122 AAI12123 BC112124 AAI12125 CU449837 HG510303 XM_011527673 XP_011525975 NM_133492 NP_597999
Function	Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 8.0. Has a highly restricted substrate specificity for the natural stereoisomer of ceramide with D-erythro-sphingosine but not D-ribo- phytosphingosine or D-erythro-dihydrosphingosine as a backbone. May have a role in regulating the levels of bioactive lipids ceramide and sphingosine 1-phosphate, as well as complex sphingolipids (By similarity). {ECO:0000250}.
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Tissue Specificity	Mainly expressed in epidermis. {ECO:0000269|PubMed:16477081}.
Top Pathways	Sphingolipid signaling pathway, Sphingolipid metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

ACER1 / ASAH3 Antibody Blocking Peptide - LS-E6060 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ACER1 / ASAH3 Antibody Blocking Peptide - LS-E22256 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ACER1 / ASAH3 Antibody Blocking Peptide - LS-E22255 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ACER1-Antibody-C-term-Blocking-Peptide - BP18654b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ACER1 Blocking Peptide - 33R-9701 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

ACER1 Blocking Peptide - 33R-4174 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

ACER1 Blocking Peptide - abx064285 from Abbexa Category Peptide Species Human, Mouse, Rat, Monkey

ACER1 fusion protein - ag18488 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human ACER1, GST-tagged - ACER1-9287H from Creative Biomart Category Protein Source E.coli Species Human

ACER1 Blocking Peptide - CBP3091 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Monkey

Alkaline ceramidase 1 - TP311332 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

ASAH3 Protein - NBP1-90090PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

ACER1 Peptide, Human - M34GP00131H from Creative Peptides Category Peptide Source Synthetic. Species Human

ACER1 peptide - orb218954 from Biorbyt Category Peptide Species Human, Mouse

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