Gene Symbol | HSPBP1 |
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Entrez Gene | 23640 |
Alt Symbol | FES1 |
Species | Human |
Gene Type | protein-coding |
Description | HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1 |
Other Description | heat shock protein-binding protein 1|hsp70 interacting protein|hsp70-binding protein 1 |
Swissprots | B3KQP0 Q9NZL4 O95351 Q6ZNU5 B4DG11 |
Accessions | CAF86633 EAW72355 EAW72356 EAW72357 EAW72358 Q9NZL4 AB020592 BAB18742 AF093420 AAC79703 AF187859 AAF35833 AF217996 AAG17238 AI859141 AK075293 BAG52102 AK129755 AK130636 BAC85399 AK130781 AK294358 BAG57622 BC001236 AAH01236 BC002373 AAH02373 BM853303 BU630679 CR457118 CAG33399 DB500673 DQ893570 ABM84496 DQ894424 ABM85350 EU176268 ABW03719 XM_005258700 XP_005258757 XM_005258701 XP_005258758 XM_011526691 XP_011524993 NM_001130106 NP_001123578 NM_001297600 NP_001284529 NM_012267 NP_036399 |
Function | Inhibits HSPA1A chaperone activity by changing the conformation of the ATP-binding domain of HSPA1A and interfering with ATP binding. Interferes with ubiquitination mediated by STUB1 and inhibits chaperone-assisted degradation of immature CFTR. {ECO:0000269|PubMed:10786638, ECO:0000269|PubMed:12651857, ECO:0000269|PubMed:15215316, ECO:0000269|PubMed:9830037}. |
Tissue Specificity | Ubiquitous. {ECO:0000269|PubMed:9830037}. |
Top Pathways | Protein processing in endoplasmic reticulum |
HspBP1 CRISPR/Cas9 KO Plasmid (h) - sc-406487 from Santa Cruz Biotechnology
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HspBP1 HDR Plasmid (h) - sc-406487-HDR from Santa Cruz Biotechnology
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HspBP1 Double Nickase Plasmid (h) - sc-406487-NIC from Santa Cruz Biotechnology
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HspBP1 Double Nickase Plasmid (h2) - sc-406487-NIC-2 from Santa Cruz Biotechnology
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HspBP1 CRISPR Activation Plasmid (h) - sc-406487-ACT from Santa Cruz Biotechnology
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HspBP1 CRISPR Activation Plasmid (h2) - sc-406487-ACT-2 from Santa Cruz Biotechnology
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HspBP1 Lentiviral Activation Particles (h) - sc-406487-LAC from Santa Cruz Biotechnology
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HspBP1 Lentiviral Activation Particles (h2) - sc-406487-LAC-2 from Santa Cruz Biotechnology
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HspBP1 siRNA (h) - sc-45314 from Santa Cruz Biotechnology
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HspBP1 shRNA Plasmid (h) - sc-45314-SH from Santa Cruz Biotechnology
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HspBP1 shRNA (h) Lentiviral Particles - sc-45314-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU021791 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10380 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10380 from Sigma-Aldrich
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HSPBP1 siRNA (Human) - CRH8415 from Cohesion Biosciences
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HSPBP1 - MBS8237427 from MyBioSource
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shRNA set against Human HSPBP1 (NM_012267.4) - SHH315753 from Creative biogene
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HspBP1 CRISPR/Cas9 KO Plasmid (h2) - sc-406487-KO-2 from Santa Cruz Biotechnology
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HspBP1 HDR Plasmid (h2) - sc-406487-HDR-2 from Santa Cruz Biotechnology
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HSPBP1 shRNA Plasmid (Human) - CHH8415 from Cohesion Biosciences
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HSPBP1 miRNA 3'UTR clone - MiUTR3H-12693 from Creative biogene
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HSPBP1 miRNA 3'UTR clone - MiUTR3H-12694 from Creative biogene
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