| Gene Symbol | XPC |
|---|---|
| Entrez Gene | 7508 |
| Alt Symbol | RAD4, XP3, XPCC, p125 |
| Species | Human |
| Gene Type | protein-coding |
| Description | xeroderma pigmentosum, complementation group C |
| Other Description | DNA repair protein complementing XP-C cells|mutant xeroderma pigmentosum group C |
| Swissprots | E9PB96 Q01831 E9PH69 B4DIP3 Q96AX0 Q53GT7 |
| Accessions | AAF87574 AAM77801 AAZ43079 AAZ43080 AAZ43081 ACE74247 ACE74248 ACE74249 ACE74250 ACE74251 ACE74252 ACE74253 ACE74254 ACE74255 EAW64188 EAW64189 Q01831 AI091587 AK222844 BAD96564 AK289761 BAF82450 AK295711 BAG58555 AK311039 AL710884 BC016620 AAH16620 D21089 BAA04651 EU530522 ACD74563 EU530523 ACD74564 EU530524 ACD74565 EU530525 ACD74566 EU530526 ACD74567 EU530527 ACD74568 EU530529 ACD74569 EU530531 ACD74570 EU530532 ACD74571 EU530533 ACD74572 EU530534 ACD74573 HM113488 ADI50189 KJ534962 AHW56602 KJ535085 AHW56724 X65024 CAA46158 XM_011534092 XP_011532394 XM_011534093 XP_011532395 NM_004628 NP_004619 NR_027299 NM_001145769 |
| Function | Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA- binding activity. |
| Subcellular Location | Nucleus. Cytoplasm. Note=Omnipresent in the nucleus and consistently associates with and dissociates from DNA in the absence of DNA damage. Continuously shuttles between the cytoplasm and the nucleus, which is impeded by the presence of NER lesions. |
| Top Pathways | Nucleotide excision repair |