XPC

Gene Symbol XPC
Entrez Gene 7508
Alt Symbol RAD4, XP3, XPCC, p125
Species Human
Gene Type protein-coding
Description xeroderma pigmentosum, complementation group C
Other Description DNA repair protein complementing XP-C cells|mutant xeroderma pigmentosum group C
Swissprots E9PB96 Q01831 E9PH69 B4DIP3 Q96AX0 Q53GT7
Accessions AAF87574 AAM77801 AAZ43079 AAZ43080 AAZ43081 ACE74247 ACE74248 ACE74249 ACE74250 ACE74251 ACE74252 ACE74253 ACE74254 ACE74255 EAW64188 EAW64189 Q01831 AI091587 AK222844 BAD96564 AK289761 BAF82450 AK295711 BAG58555 AK311039 AL710884 BC016620 AAH16620 D21089 BAA04651 EU530522 ACD74563 EU530523 ACD74564 EU530524 ACD74565 EU530525 ACD74566 EU530526 ACD74567 EU530527 ACD74568 EU530529 ACD74569 EU530531 ACD74570 EU530532 ACD74571 EU530533 ACD74572 EU530534 ACD74573 HM113488 ADI50189 KJ534962 AHW56602 KJ535085 AHW56724 X65024 CAA46158 XM_011534092 XP_011532394 XM_011534093 XP_011532395 NM_004628 NP_004619 NR_027299 NM_001145769
Function Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA- binding activity.
Subcellular Location Nucleus. Cytoplasm. Note=Omnipresent in the nucleus and consistently associates with and dissociates from DNA in the absence of DNA damage. Continuously shuttles between the cytoplasm and the nucleus, which is impeded by the presence of NER lesions.
Top Pathways Nucleotide excision repair

XPC (D1M5Y) Rabbit mAb - 14768 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D1M5Y
Western blot analysis of extracts from MCF7 and MDA-MB-231 cells using XPC (D1M5Y) Rabbit mAb (upper) and α-Actinin (D6F6) XP ® Rabbit mAb #6487 (lower).

XPC Antibody - 12701 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines using XPC Antibody.

XPC (A-5) - sc-74411 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
XPC (A-5): sc-74411. Western blot analysis of XPC expression in Hs68 (A) and Raji (B) whole cell lysates.

XPC (D-10) - sc-74410 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
XPC (D-10): sc-74410. Western blot analysis of XPC expression in Hs68 (A) and Raji (B) whole cell lysates.

XPC (D-18) - sc-22535 from Santa Cruz Biotechnology

Prices $61.00
Sizes 100 µg/0.5 ml
Host Goat
Clonality Polyclonal
XPC (D-18): sc-22535. Immunoperoxidase staining of formalin fixed, paraffin-embedded human skin tissue showing nuclear and cytoplasmic staining of epidermal cells.

XPC (H-300) - sc-30156 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
XPC (H-300): sc-30156. Immunoperoxidase staining of formalin fixed, paraffin-embedded human fallopian tube tissue showing nuclear staining of glandular cells at low (A) and high (B) magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.

Anti-XPC antibody - ab78064 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ab78064 (5µg/ml) staining XPC in formalin-fixed, paraffin-embedded human brain cortex tissue sections. A biotin-conjugated goat anti-rabbit IgG was used as the secondary.

Anti-XPC antibody [3.26] - ab6264 from Abcam

Prices $400.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3.26
Lane 1 : Anti-XPC antibody [3.26] (ab6264) at 1/1000 dilutionLane 2 : Anti-XPC antibody [3.26] (ab6264) at 1/500 dilutionLane 1 : Raji whole cell extractLane 2 : Raji whole cell extract

Anti-XPC antibody - C-terminal - ab155025 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-XPC antibody - C-terminal (ab155025) at 1/500 dilution + IMR32 whole cell lysate at 30 µg

Anti-XPC antibody - N-terminal - ab156191 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-XPC antibody - N-terminal (ab156191) at 1/100 dilution + ZR-75-1 cell line at 35 µg

Anti-XPC Antibody (N-Terminus) - LS-C20102 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-XPC Antibody (aa890-940) - LS-C90763 from LifeSpan Bioscience

Prices $545.00
Sizes 20 µg
Host Rabbit
Clonality Polyclonal

Anti-XPC Antibody (C-Terminus) - LS-C153428 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-XPC Antibody (aa154-183, AP) - LS-C242799 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-XPC Antibody (aa154-183, FITC) - LS-C242800 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-XPC Antibody (aa154-183, Biotin) - LS-C242801 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-XPC Antibody (aa154-183, APC) - LS-C242802 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-XPC Antibody (aa154-183, PE) - LS-C242803 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-XPC Antibody (aa154-183, Azide-free, HRP) - LS-C247262 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-XPC Antibody - LS-C285639 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-XPC Antibody (aa825-875) - LS-C287949 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-XPC Antibody (aa890-940) - LS-C287950 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-XPC Antibody (aa734-933, Biotin) - LS-C300021 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-XPC Antibody (aa734-933, FITC) - LS-C302282 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-XPC Antibody (clone 6D11) - LS-C198444 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 6D11
Detection limit for recombinant GST tagged XPC is approximately 0.03 ng/ml as a capture antibody.
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