XPC

Gene Symbol	XPC
Entrez Gene	7508
Alt Symbol	RAD4, XP3, XPCC, p125
Species	Human
Gene Type	protein-coding
Description	xeroderma pigmentosum, complementation group C
Other Description	DNA repair protein complementing XP-C cells|mutant xeroderma pigmentosum group C
Swissprots	E9PB96 Q01831 E9PH69 B4DIP3 Q96AX0 Q53GT7
Accessions	AAF87574 AAM77801 AAZ43079 AAZ43080 AAZ43081 ACE74247 ACE74248 ACE74249 ACE74250 ACE74251 ACE74252 ACE74253 ACE74254 ACE74255 EAW64188 EAW64189 Q01831 AI091587 AK222844 BAD96564 AK289761 BAF82450 AK295711 BAG58555 AK311039 AL710884 BC016620 AAH16620 D21089 BAA04651 EU530522 ACD74563 EU530523 ACD74564 EU530524 ACD74565 EU530525 ACD74566 EU530526 ACD74567 EU530527 ACD74568 EU530529 ACD74569 EU530531 ACD74570 EU530532 ACD74571 EU530533 ACD74572 EU530534 ACD74573 HM113488 ADI50189 KJ534962 AHW56602 KJ535085 AHW56724 X65024 CAA46158 XM_011534092 XP_011532394 XM_011534093 XP_011532395 NM_004628 NP_004619 NR_027299 NM_001145769
Function	Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA- binding activity.
Subcellular Location	Nucleus. Cytoplasm. Note=Omnipresent in the nucleus and consistently associates with and dissociates from DNA in the absence of DNA damage. Continuously shuttles between the cytoplasm and the nucleus, which is impeded by the presence of NER lesions.
Top Pathways	Nucleotide excision repair

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Recombinant Human XPC Protein - H00007508-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Human XPC protein - orb244633 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

XPC / XPCC - H00007508-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

XPC / XPCC - H00007508-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

XPC Peptide - 350531 from ABBIOTEC Category Peptide Prices $50.00 Sizes 100 µg

Recombinant Xeroderma Pigmentosum, Complementation Group C (XPC) - RPA473Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Xeroderma Pigmentosum, Complementation Group C (XPC) - RPA473Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Xeroderma Pigmentosum, Complementation Group C (XPC) - RPA473Mu02 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Xeroderma Pigmentosum, Complementation Group C (XPC) - RPA473Ra01 from Uscn Life Science Inc. Category Protein Source E.coli Species Rat

Recombinant Xeroderma Pigmentosum, Complementation Group C (XPC) - RPA473Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human DNA repair protein complementing XP-C cells(XPC) ,partial - CSB-YP026217HU CSB-BP026217HU CSB-MP026217HU from Cusabio Category Protein Source Yeast or Baculovirus or Mammalian cell Species Human

Recombinant human DNA repair protein complementing XP-C cells - CSB-EP026217HU from Cusabio Category Protein Source E.coli Species Human

XPC Protein - abx163204 from Abbexa Category Protein Species Human

XPC Recombinant Protein Antigen - NBP2-38261PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

XPC-Blocking-PeptideN-term - BP19709a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

XPC Peptide, Human - M34GP17582H from Creative Peptides Category Peptide Source Synthetic. Species Human

XPC Recombinant Protein (OPCA01929) - OPCA01929 from Aviva Systems Biology Category Protein Prices $250.00 Sizes 50 µg Source Human

Recombinant human DNA repair protein complementing XP-C cells - AP70922 from Signalway Antibody Category Protein Prices $260.00, $735.00, $1,240.00, $1,975.00 Sizes 50 µg, 200 µg, 500 µg, 1 mg Source E.coli Species Human

DNA repair protein complementing XP-C cells, Recombinant Protein - MBS9420808 from MyBioSource Category Protein Prices $280.00, $665.00, $1,080.00, $1,690.00 Sizes 50 µg, 200 µg, 500 µg, 1 mg Source E Coli Species Human

DNA repair protein complementing XP-C cells , Recombinant Protein - MBS960949 from MyBioSource Category Protein Prices $190.00, $460.00, $750.00, $1,180.00 Sizes 50 µg (E-Coli), 200 µg (E-Coli), 500 µg (E-Coli), 1 mg (E-Coli) Source E Coli or Yeast or Baculovirus or Mammalian Cell

XPC Recombinant Protein Antigen - NBP2-57657PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Recombinant Human XPC Protein (496-734 aa), His-tagged - XPC-848H from Creative Biomart Category Protein Source E. coli Species Human

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