| Gene Symbol |
NCF4
|
| Entrez Gene |
4689
|
| Alt Symbol |
NCF, P40PHOX, SH3PXD4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
neutrophil cytosolic factor 4, 40kDa
|
| Other Description |
NCF-4|SH3 and PX domain-containing protein 4|neutrophil NADPH oxidase factor 4|neutrophil cytosol factor 4|p40-phox
|
| Swissprots |
Q86U56 Q15080 Q9BU98 Q9NP45 O60808 A8K4F9
|
| Accessions |
AAB39970 ABC40739 EAW60122 EAW60123 EAW60124 Q15080 AB025219 BAA89791 AB025220 BAA89792 AK223324 BAD97044 AK290924 BAF83613 BC002798 AAH02798 BT007346 AAP36010 BU076892 BX355636 CR456528 CAG30414 CR542078 CAG46875 CU013128 CAK54559 CU013416 CAK54858 X77094 CAA54372 XM_011530198 XP_011528500 XM_011530199 XP_011528501 NM_000631 NP_000622 NM_013416 NP_038202
|
| Function |
Component of the NADPH-oxidase, a multicomponent enzyme system responsible for the oxidative burst in which electrons are transported from NADPH to molecular oxygen, generating reactive oxidant intermediates. It may be important for the assembly and/or activation of the NADPH-oxidase complex. {ECO:0000269|PubMed:8280052}.
|
| Subcellular Location |
Cytoplasm, cytosol. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Membrane; Peripheral membrane protein.
|
| Tissue Specificity |
Expression is restricted to hematopoietic cells.
|
| Top Pathways |
Leukocyte transendothelial migration, Leishmaniasis, Phagosome, Osteoclast differentiation
|