Gene Symbol | NCF4 |
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Entrez Gene | 4689 |
Alt Symbol | NCF, P40PHOX, SH3PXD4 |
Species | Human |
Gene Type | protein-coding |
Description | neutrophil cytosolic factor 4, 40kDa |
Other Description | NCF-4|SH3 and PX domain-containing protein 4|neutrophil NADPH oxidase factor 4|neutrophil cytosol factor 4|p40-phox |
Swissprots | Q86U56 Q15080 Q9BU98 Q9NP45 O60808 A8K4F9 |
Accessions | AAB39970 ABC40739 EAW60122 EAW60123 EAW60124 Q15080 AB025219 BAA89791 AB025220 BAA89792 AK223324 BAD97044 AK290924 BAF83613 BC002798 AAH02798 BT007346 AAP36010 BU076892 BX355636 CR456528 CAG30414 CR542078 CAG46875 CU013128 CAK54559 CU013416 CAK54858 X77094 CAA54372 XM_011530198 XP_011528500 XM_011530199 XP_011528501 NM_000631 NP_000622 NM_013416 NP_038202 |
Function | Component of the NADPH-oxidase, a multicomponent enzyme system responsible for the oxidative burst in which electrons are transported from NADPH to molecular oxygen, generating reactive oxidant intermediates. It may be important for the assembly and/or activation of the NADPH-oxidase complex. {ECO:0000269|PubMed:8280052}. |
Subcellular Location | Cytoplasm, cytosol. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Membrane; Peripheral membrane protein. |
Tissue Specificity | Expression is restricted to hematopoietic cells. |
Top Pathways | Leukocyte transendothelial migration, Leishmaniasis, Phagosome, Osteoclast differentiation |
p40-phox CRISPR/Cas9 KO Plasmid (h) - sc-401461 from Santa Cruz Biotechnology
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p40-phox HDR Plasmid (h) - sc-401461-HDR from Santa Cruz Biotechnology
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p40-phox Double Nickase Plasmid (h) - sc-401461-NIC from Santa Cruz Biotechnology
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p40-phox Double Nickase Plasmid (h2) - sc-401461-NIC-2 from Santa Cruz Biotechnology
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p40-phox CRISPR Activation Plasmid (h) - sc-401461-ACT from Santa Cruz Biotechnology
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p40-phox CRISPR Activation Plasmid (h2) - sc-401461-ACT-2 from Santa Cruz Biotechnology
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p40-phox Lentiviral Activation Particles (h) - sc-401461-LAC from Santa Cruz Biotechnology
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p40-phox Lentiviral Activation Particles (h2) - sc-401461-LAC-2 from Santa Cruz Biotechnology
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p40-phox siRNA (h) - sc-36155 from Santa Cruz Biotechnology
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p40-phox shRNA Plasmid (h) - sc-36155-SH from Santa Cruz Biotechnology
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p40-phox shRNA (h) Lentiviral Particles - sc-36155-V from Santa Cruz Biotechnology
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NCF4 RNAi - H00004689-R02 from Novus Biologicals
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NCF4 RNAi - H00004689-R01 from Novus Biologicals
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MISSION® esiRNA - EHU082481 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN15017 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15017 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03420 from Sigma-Aldrich
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NCF4 siRNA (Human) - CRH3104 from Cohesion Biosciences
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shRNA set against Human NCF4 (NM_000631.4) - SHH349956 from Creative biogene
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shRNA set against Human NCF4(NM_000631.4) - SHR000510 from Creative biogene
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shRNA set against Human NCF4(NM_013416.3) - SHR000546 from Creative biogene
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Human NCF4 siRNA - orb263606 from Biorbyt
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NCF4 shRNA Plasmid (Human) - CHH3104 from Cohesion Biosciences
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NCF4 miRNA 3'UTR clone - MiUTR1H-06673 from Creative biogene
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NCF4 miRNA 3'UTR clone - MiUTR1H-06674 from Creative biogene
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