MAP3K9

Gene Symbol MAP3K9
Entrez Gene 4293
Alt Symbol MEKK9, MLK1, PRKE1
Species Human
Gene Type protein-coding
Description mitogen-activated protein kinase kinase kinase 9
Other Description mixed lineage kinase 1 (tyr and ser/thr specificity)
Swissprots Q9H2N5 Q0D2G7 Q6EH31 A3KN85 P80192
Accessions EAW81045 EAW81046 P80192 AF251442 AAG44591 AK091645 BAG52397 AK123430 AK294571 BAG57765 AK299727 BAG61625 AK302849 BAG64036 AY327900 AAQ23054 BC033197 AAH33197 BC040716 BC043010 BC111407 AAI11408 BC133706 AAI33707 BX648924 DB099391 XM_005267683 XP_005267740 XM_011536788 XP_011535090 XM_011536789 XP_011535091 XM_011536790 XP_011535092 XM_011536791 XP_011535093 XM_011536792 XP_011535094 XM_011536793 XP_011535095 XM_011536794 XP_011535096 NM_001284230 NP_001271159 NM_001284231 NP_001271160 NM_001284232 NP_001271161 NM_033141 NP_149132
Function Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade through the phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7 which in turn activate the JNKs. The MKK/JNK signaling pathway regulates stress response via activator protein-1 (JUN) and GATA4 transcription factors. Plays also a role in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. {ECO:0000269|PubMed:11416147, ECO:0000269|PubMed:15610029}.
Tissue Specificity Expressed in epithelial tumor cell lines of colonic, breast and esophageal origin. {ECO:0000269|PubMed:8477742}.

MLK1 (D66E2) Rabbit mAb - 5029 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D66E2
Western blot analysis of extracts from various cell lines using MLK1 (D66E2) Rabbit mAb.

MLK1 (N-20) - sc-19120 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

MLK1 (H-96) - sc-366887 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

MLK1 (S-19) - sc-19121 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-MAP3K9 +MAP3K10 (phospho T312 + T266) antibody - ab111389 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab111389 at 1/50 dilution staining MAP3K9 +MAP3K10 in paraffin-embedded Human breast carcinoma tissue by Immunohistochemistry. The image on the right is treated with synthesized phosphopeptide.

Anti-MAP3K9 antibody - ab154506 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-MAP3K9 antibody (ab154506) at 1/500 dilution + A431 whole cell lysate at 30 µg

Anti-MAP3K9 antibody - ab157006 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-MAP3K9 antibody (ab157006) at 1/500 dilution (for 2 hrs at RT)Lane 1 : HeLa total cell extractLane 2 : Mouse thymus total cell extract

Anti-MAP3K9 antibody - C-terminal - ab71628 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-MAP3K9 antibody - C-terminal (ab71628) at 1/100 dilutionLane 1 : A375 cell lysate Lane 2 : rat testis tissue lysate Lysates/proteins at 12.5 µg per lane.

Anti-MAP3K9 / MLK1 Antibody (C-Terminus, APC) - LS-C279165 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MAP3K9 / MLK1 Antibody - LS-C190111 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-MAP3K9 / MLK1 Antibody (C-Terminus, AP) - LS-C279164 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MAP3K9 / MLK1 Antibody (C-Terminus, Biotin) - LS-C279166 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MAP3K9 / MLK1 Antibody (C-Terminus, FITC) - LS-C279167 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MAP3K9 / MLK1 Antibody (C-Terminus, Azide-free, HRP) - LS-C279168 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MAP3K9 / MLK1 Antibody (C-Terminus, AP) - LS-C279170 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MAP3K9 / MLK1 Antibody (C-Terminus, APC) - LS-C279171 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MAP3K9 / MLK1 Antibody (aa561-610) - LS-C199223 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded human colon carcinoma tissue, using MAP3K9 Antibody. The sample on the right was incubated with synthetic peptide.

Anti-MAP3K9 / MLK1 Antibody (C-Terminus, PE) - LS-C279169 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MAP3K9 / MLK1 Antibody (C-Terminus, Azide-free, HRP) - LS-C279174 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MAP3K9 / MLK1 Antibody (C-Terminus, Biotin) - LS-C279172 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MAP3K9 / MLK1 Antibody (C-Terminus, FITC) - LS-C279173 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MAP3K9 / MLK1 Antibody (C-Terminus, PE) - LS-C279175 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MAP3K9 / MLK1 Antibody (C-Terminus) - LS-C327817 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MAP3K9 / MLK1 Antibody (C-Terminus) - LS-C330527 from LifeSpan Bioscience

Prices $425.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MAP3K9 / MLK1 Antibody (aa1070-1104) - LS-C99488 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
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