MAP3K9

Gene Symbol MAP3K9
Entrez Gene 4293
Alt Symbol MEKK9, MLK1, PRKE1
Species Human
Gene Type protein-coding
Description mitogen-activated protein kinase kinase kinase 9
Other Description mixed lineage kinase 1 (tyr and ser/thr specificity)
Swissprots Q9H2N5 Q0D2G7 Q6EH31 A3KN85 P80192
Accessions EAW81045 EAW81046 P80192 AF251442 AAG44591 AK091645 BAG52397 AK123430 AK294571 BAG57765 AK299727 BAG61625 AK302849 BAG64036 AY327900 AAQ23054 BC033197 AAH33197 BC040716 BC043010 BC111407 AAI11408 BC133706 AAI33707 BX648924 DB099391 XM_005267683 XP_005267740 XM_011536788 XP_011535090 XM_011536789 XP_011535091 XM_011536790 XP_011535092 XM_011536791 XP_011535093 XM_011536792 XP_011535094 XM_011536793 XP_011535095 XM_011536794 XP_011535096 NM_001284230 NP_001271159 NM_001284231 NP_001271160 NM_001284232 NP_001271161 NM_033141 NP_149132
Function Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade through the phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7 which in turn activate the JNKs. The MKK/JNK signaling pathway regulates stress response via activator protein-1 (JUN) and GATA4 transcription factors. Plays also a role in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. {ECO:0000269|PubMed:11416147, ECO:0000269|PubMed:15610029}.
Tissue Specificity Expressed in epithelial tumor cell lines of colonic, breast and esophageal origin. {ECO:0000269|PubMed:8477742}.

MAP3K9 Overexpression Lysate (Native) - NBP2-05914 from Novus Biologicals

Category Cell Lysate
Prices $529.00
Sizes 100 µg
Western Blot: MAP3K9 Overexpression Lysate (Adult Normal) [NBP2-05914] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for MAP3K9.

Panoply™ Human MAP3K9 Knockdown Stable Cell Line - CSC-DC009179 from Creative biogene

Category Cell Line
Species Human
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