TGFB1I1

Gene Symbol TGFB1I1
Entrez Gene 7041
Alt Symbol ARA55, HIC-5, HIC5, TSC-5
Species Human
Gene Type protein-coding
Description transforming growth factor beta 1 induced transcript 1
Other Description androgen receptor coactivator 55 kDa protein|androgen receptor coactivator ARA55|androgen receptor-associated protein of 55 kDa|hydrogen peroxide-inducible clone 5 protein|hydrogen peroxide-inducible clone-5|transforming growth factor beta-1-induced transcript 1 protein
Swissprots Q9Y2V5 Q9BPW3 O43294 B2R8D5
Accessions ABB96286 EAW52126 EAW52127 EAW52128 EAW52129 EAW52130 O43294 AA992124 AB007836 BAA24799 AF116343 AAD22552 AK122975 AK313327 BAG36132 BC001507 AAH01507 BC001830 AAH01830 BC017288 AAH17288 BC032545 AAH32545 DA097743 NM_001042454 NP_001035919 NM_001164719 NP_001158191 NM_015927 NP_057011
Function Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA- binding activity. {ECO:0000269|PubMed:10075738, ECO:0000269|PubMed:11463817, ECO:0000269|PubMed:11856738, ECO:0000269|PubMed:12177201, ECO:0000269|PubMed:12445807, ECO:0000269|PubMed:12700349, ECO:0000269|PubMed:15211577, ECO:0000269|PubMed:15561701, ECO:0000269|PubMed:16141357, ECO:0000269|PubMed:16624805, ECO:0000269|PubMed:16803
Subcellular Location Cell junction, focal adhesion. Nucleus matrix. Cytoplasm, cytoskeleton. Note=Associated with the actin cytoskeleton; colocalizes with stress fibers.
Tissue Specificity Expressed in platelets, smooth muscle and prostate stromal cells (at protein level). {ECO:0000269|PubMed:10075738, ECO:0000269|PubMed:10708479, ECO:0000269|PubMed:11311131, ECO:0000269|PubMed:12642630, ECO:0000269|PubMed:12772188, ECO:0000269|PubMed:16849583, ECO:0000269|PubMed:17166536, ECO:0000269|PubMed:17233630, ECO:0000269|PubMed:9664039}.

Hic-5 Antibody - 4914 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from U-2-OS, COS-7 and A-431 cells using Hic-5 Antibody.

Hic-5 (C-6) - sc-271353 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Hic-5 (C-6): sc-271353. Western blot analysis of Hic-5 expression in non-transfected: sc-117752 (A) and mouse Hic-5 transfected: sc-126953 (B) 293T whole cell lysates.

Hic-5 (C-15) - sc-17616 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Hic-5 (C-15): sc-17616. Western blot analysis of Hic-5 expression in non-transfected: sc-117752 (A) and mouse Hic-5 transfected: sc-126953 (B) 293T whole cell lysates.

Hic-5 (D-15) - sc-30972 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Hic-5 (D-15): sc-30972. Western blot analysis of Hic-5 expression in non-transfected: sc-117752 (A) and mouse Hic-5 transfected: sc-126953 (B) 293T whole cell lysates.

Hic-5 (H-1) - sc-271447 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Hic-5 (H-1): sc-271447. Western blot analysis of Hic-5 expression in non-transfected: sc-117752 (A) and mouse Hic-5 transfected: sc-126953 (B) 293T whole cell lysates.

Hic-5 (F-6) - sc-137051 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Hic-5 (F-6): sc-137051. Western blot analysis of Hic-5 expression in non-transfected: sc-117752 (A) and human Hic-5 transfected: sc-115206 (B) 293T whole cell lysates.

Hic-5 (H-75) - sc-28748 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Hic-5 (H-75): sc-28748. Western blot analysis of Hic-5 expression in non-transfected: sc-117752 (A) and human Hic-5 transfected: sc-115206 (B) 293T whole cell lysates.

Hic-5 (P-19) - sc-30971 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-HIC5 antibody - ab83273 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-HIC5 antibody (ab83273) at 1 µg/ml + transfected 293T cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-HIC5 antibody - ab57754 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-ARA55 / HIC-5 Antibody (N-Terminus) IHC-plus™ - LS-B3528 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-TGFB1I1 / HIC-5 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3528 concentration 5 ug/ml.

Anti-ARA55 / HIC-5 Antibody (aa256-461, Biotin) - LS-C297039 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ARA55 / HIC-5 Antibody (aa252-461, Biotin) - LS-C301099 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ARA55 / HIC-5 Antibody (aa252-461, FITC) - LS-C304016 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ARA55 / HIC-5 Antibody (aa256-461, FITC) - LS-C304017 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ARA55 / HIC-5 Antibody (aa1-445, Azide-free) - LS-C328933 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-ARA55 / HIC-5 Antibody (aa31-80) - LS-C199056 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded human lung carcinoma tissue, using Hic-5 Antibody. The sample on the right was incubated with synthetic peptide.

Anti-ARA55 / HIC-5 Antibody (aa252-461) - LS-C296760 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant ARA55 / HIC-5.

Anti-ARA55 / HIC-5 Antibody (aa256-461) - LS-C296763 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant ARA55 / HIC-5.

Anti-ARA55 / HIC-5 Antibody (clone 4B2-D8) - LS-C198338 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4B2-D8
Western Blot analysis of TGFB1I1 expression in transfected 293T cell line by TGFB1I1 monoclonal antibody (M01), clone 4B2-D8.Lane 1: TGFB1I1 transfected lysate(47.9 KDa).Lane 2: Non-transfected lysate.

Anti-ARA55 / HIC-5 Antibody (aa179-228) IHC-plus™ - LS-B1004 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-TGFB1I1 / HIC-5 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B1004 concentration 5 ug/ml.

HIC5/TGFB1I1 Antibody - NBP1-90116 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: HIC5 Antibody [NBP1-90116] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11<br/>Lane 2: Human cell line RT-4<br/>Lane 3: Human cell line U-251MG sp<br/>Lane 4: Human plasma (IgG/HSA depleted)<br/>Lane 5: Human liver tissue<br/>Lane 6: Human tonsil tissue

HIC5/TGFB1I1 Antibody [Unconjugated] - AF5626 from Novus Biologicals

Prices $99.00, $329.00
Sizes 25 µg, 100 µg
Host Goat
Clonality Polyclonal
Western blot shows lysates of MCF‑7 human breast cancer cell line and HepG2 human hepatocellular carcinoma cell line. PVDF membrane was probed with 1 µg/mL of Goat Anti-Human HIC5/TGFB1I1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF5626) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF109). A specific band was detected for HIC5/TGFB1I1 at approximately 50 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

HIC5/TGFB1I1 Antibody - H00007041-D01P from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

HIC5/TGFB1I1 Antibody (4B2-D8) - H00007041-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4B2-D8
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