| Gene Symbol |
TGFB1I1
|
| Entrez Gene |
7041
|
| Alt Symbol |
ARA55, HIC-5, HIC5, TSC-5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
transforming growth factor beta 1 induced transcript 1
|
| Other Description |
androgen receptor coactivator 55 kDa protein|androgen receptor coactivator ARA55|androgen receptor-associated protein of 55 kDa|hydrogen peroxide-inducible clone 5 protein|hydrogen peroxide-inducible clone-5|transforming growth factor beta-1-induced transcript 1 protein
|
| Swissprots |
Q9Y2V5 Q9BPW3 O43294 B2R8D5
|
| Accessions |
ABB96286 EAW52126 EAW52127 EAW52128 EAW52129 EAW52130 O43294 AA992124 AB007836 BAA24799 AF116343 AAD22552 AK122975 AK313327 BAG36132 BC001507 AAH01507 BC001830 AAH01830 BC017288 AAH17288 BC032545 AAH32545 DA097743 NM_001042454 NP_001035919 NM_001164719 NP_001158191 NM_015927 NP_057011
|
| Function |
Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA- binding activity. {ECO:0000269|PubMed:10075738, ECO:0000269|PubMed:11463817, ECO:0000269|PubMed:11856738, ECO:0000269|PubMed:12177201, ECO:0000269|PubMed:12445807, ECO:0000269|PubMed:12700349, ECO:0000269|PubMed:15211577, ECO:0000269|PubMed:15561701, ECO:0000269|PubMed:16141357, ECO:0000269|PubMed:16624805, ECO:0000269|PubMed:16803
|
| Subcellular Location |
Cell junction, focal adhesion. Nucleus matrix. Cytoplasm, cytoskeleton. Note=Associated with the actin cytoskeleton; colocalizes with stress fibers.
|
| Tissue Specificity |
Expressed in platelets, smooth muscle and prostate stromal cells (at protein level). {ECO:0000269|PubMed:10075738, ECO:0000269|PubMed:10708479, ECO:0000269|PubMed:11311131, ECO:0000269|PubMed:12642630, ECO:0000269|PubMed:12772188, ECO:0000269|PubMed:16849583, ECO:0000269|PubMed:17166536, ECO:0000269|PubMed:17233630, ECO:0000269|PubMed:9664039}.
|
