AP1S3
| Gene Symbol | AP1S3 |
|---|---|
| Entrez Gene | 130340 |
| Alt Symbol | PSORS15 |
| Species | Human |
| Gene Type | protein-coding |
| Description | adaptor-related protein complex 1, sigma 3 subunit |
| Other Description | AP-1 complex subunit sigma-3|adapter-related protein complex 1 subunit sigma-1C|adaptor protein complex AP-1 sigma-1C subunit|adaptor-related protein complex 1 subunit sigma-1C|clathrin assembly protein complex 1 sigma-1C small chain|golgi adaptor HA1/AP1 adaptin sigma-1C subunit|sigma 1C subunit of AP-1 clathrin |
| Swissprots | B4DQZ1 Q96DD1 Q8WTY1 Q96PC3 |
| Accessions | AAY24166 AAY24244 EAW70813 EAW70814 EAW70815 EAW70816 Q96PC3 AF393369 AAL09586 AK025338 AK299026 BAG61103 BC009606 AAH09606 BC021898 AAH21898 BE856458 BG177582 BG340480 XM_011510600 XP_011508902 NM_001039569 NP_001034658 NR_110905 NR_110906 NM_178814 |
| Function | Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Involved in TLR3 trafficking (PubMed:24791904). {ECO:0000269|PubMed:24791904}. |
| Subcellular Location | Golgi apparatus. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, clathrin-coated pit. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex. |
| Tissue Specificity | Widely expressed. |
| Top Pathways | Lysosome |
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